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Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata
Li,Bin1; Kuang,Yi1; He,Jun Bin1; Tang,Rui1; Xu,Lu Lu1; Leung,Chung Hang2; Ma,Dik Lung3; Qiao,Xue1; Ye,Min1
2020-01-24
Source PublicationJournal of Natural Products
ISSN0163-3864
Volume83Issue:1Pages:45-54
AbstractAntrodia camphorata is a rare and valuable medicinal mushroom. In this work, 11 new triterpenoids, namely, antcamphorols A-K (1-11), together with 10 known triterpenoids, 12-21, were isolated from dish-cultured A. camphorata. Compound 1 is an unprecedented C lanostane-type triterpenoid featuring a methyl group at C-15 and a C-21-O-C-24 tetrahydropyran ring at C-17. Compounds 2-11 are ergostane-type triterpenoids, and they include two pairs of norergostanes 2-5. The structures of the new compounds were identified by NMR, 2D NMR, and HRESIMS data analyses. The absolute configurations of 1 and 6 were defined by X-ray diffraction data, and the absolute configuration at C-25 of 4 was determined by the modified Mosher's method. Compounds 7, 9, 10, 16, and 19 showed significant ROS scavenging activities (63.9-70.5% at 20 μM) in high-glucose-induced HUVECs. Compounds 3 and 8 exhibited moderate cytotoxic activities against U251 (IC, 9.2 μM) and MCF-7 (IC, 8.1 μM) human cancer cell lines, respectively.
DOI10.1021/acs.jnatprod.9b00580
URLView the original
Language英语
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorQiao,Xue
Affiliation1.State Key Laboratory of Natural and Biomimetic Drugs,Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education,School of Pharmaceutical Sciences,Peking University,Beijing,38 Xueyuan Road,100191,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
3.Department of Chemistry,Hong Kong Baptist University,Kowloon Tong,SWT 802,Hong Kong
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GB/T 7714
Li,Bin,Kuang,Yi,He,Jun Bin,et al. Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata[J]. Journal of Natural Products,2020,83(1):45-54.
APA Li,Bin,Kuang,Yi,He,Jun Bin,Tang,Rui,Xu,Lu Lu,Leung,Chung Hang,Ma,Dik Lung,Qiao,Xue,&Ye,Min.(2020).Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata.Journal of Natural Products,83(1),45-54.
MLA Li,Bin,et al."Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata".Journal of Natural Products 83.1(2020):45-54.
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