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Interfering with S100B–effector protein interactions for cancer therapy
Wu,Ke Jia1; Wang,Wanhe2; Wang,Hui Min David3; Leung,Chung Hang1; Ma,Dik Lung2
2020-09-01
Source PublicationDrug Discovery Today
ISSN1359-6446
Volume25Issue:9Pages:1754-1761
Abstract

S100 calcium-binding protein B (S100B) is overexpressed in various malignant tumors, where it regulates cancer cell proliferation and metabolism by physical interactions with other molecules. Interfering with S100B–effector protein interactions is a potential strategy to treat malignant tumors. Although some S100B inhibitors have been discovered by virtual screening (VS), most target the S100B–p53 interaction. Hence, there is scope for the discovery of other S100B–effector protein interaction modulators for malignant tumors. In this review, we provide an overview of S100B–effector protein interaction inhibitor discovery using VS and discuss promising S100B–effector protein interaction targets that permit in silico analysis for drug discovery.

DOI10.1016/j.drudis.2020.07.010
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000580387400024
Scopus ID2-s2.0-85088363103
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLeung,Chung Hang; Ma,Dik Lung
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao SAR,Taipa,999078,China
2.Department of Chemistry,Hong Kong Baptist University,Kowloon Tong,999077,China
3.Graduate Institute of Biomedical Engineering,National Chung Hsing University,Taichung,402,Taiwan
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wu,Ke Jia,Wang,Wanhe,Wang,Hui Min David,et al. Interfering with S100B–effector protein interactions for cancer therapy[J]. Drug Discovery Today,2020,25(9):1754-1761.
APA Wu,Ke Jia,Wang,Wanhe,Wang,Hui Min David,Leung,Chung Hang,&Ma,Dik Lung.(2020).Interfering with S100B–effector protein interactions for cancer therapy.Drug Discovery Today,25(9),1754-1761.
MLA Wu,Ke Jia,et al."Interfering with S100B–effector protein interactions for cancer therapy".Drug Discovery Today 25.9(2020):1754-1761.
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