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Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells
Wang,Wanhe1; Wu,Ke Jia2; Vellaisamy,Kasipandi1; Leung,Chung Hang2; Ma,Dik Lung1
Source PublicationAngewandte Chemie - International Edition

Gastrin-releasing peptide receptor (GRPr) plays proliferative and inflammatory roles in living systems. Here, we report a highly selective GRPr antagonist (JMV594)-tethered iridium(III) complex for probing GRPr in living cancer cells and immune cells. This probe exhibited desirable photophysical properties and also displayed negligible cytotoxicity, overcoming the inherent toxicity of the iridium(III) complex. Its long emission lifetime enabled its luminescence signal to be readily distinguished from the interfering fluorescence of organic dyes by using a time-resolved technique. This probe selectively visualized living cancer cells via specific binding to GRPr, while it also modulated the function of GRPr on TNF-α secretion in immune cells. To our knowledge, this is the first peptide-conjugated iridium(III) complex developed as a GRPr bioimaging probe and modulator of GRPr activity. This theranostic agent shows great potential at unmasking the diverse roles of GRPr in living systems.

KeywordGastrin-releasing Peptide Receptor (Grpr) Peptide-conjugated Transition-metal Complexes Theranostic Agents Time-resolved Emission Spectroscopy
URLView the original
Indexed BySCIE ; IC
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000559988700001
Scopus ID2-s2.0-85089465375
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorLeung,Chung Hang; Ma,Dik Lung
Affiliation1.Department of Chemistry,Hong Kong Baptist University,Kowloon,999077,Hong Kong
2.Institute of Chinese Medical Sciences and State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Taipa,999078,Macao
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wang,Wanhe,Wu,Ke Jia,Vellaisamy,Kasipandi,et al. Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells[J]. Angewandte Chemie - International Edition,2020,59(41):17897-17902.
APA Wang,Wanhe,Wu,Ke Jia,Vellaisamy,Kasipandi,Leung,Chung Hang,&Ma,Dik Lung.(2020).Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells.Angewandte Chemie - International Edition,59(41),17897-17902.
MLA Wang,Wanhe,et al."Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells".Angewandte Chemie - International Edition 59.41(2020):17897-17902.
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