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The emerging role of KDM5A in human cancer
Yang,Guan Jun1,2,3,4; Zhu,Ming Hui1,2,3; Lu,Xin Jiang1,2,3; Liu,Yan Jun5; Lu,Jian Fei1,2,3; Leung,Chung Hang4; Ma,Dik Lung6; Chen,Jiong1,2,3
2021-12-01
Source PublicationJournal of Hematology and Oncology
Volume14Issue:1
AbstractHistone methylation is a key posttranslational modification of chromatin, and its dysregulation affects a wide array of nuclear activities including the maintenance of genome integrity, transcriptional regulation, and epigenetic inheritance. Variations in the pattern of histone methylation influence both physiological and pathological events. Lysine-specific demethylase 5A (KDM5A, also known as JARID1A or RBP2) is a KDM5 Jumonji histone demethylase subfamily member that erases di- and tri-methyl groups from lysine 4 of histone H3. Emerging studies indicate that KDM5A is responsible for driving multiple human diseases, particularly cancers. In this review, we summarize the roles of KDM5A in human cancers, survey the field of KDM5A inhibitors including their anticancer activity and modes of action, and the current challenges and potential opportunities of this field.
KeywordCancer Drug resistance Histone methylation Jumonji C domain KDM5A Targeted therapy
DOI10.1186/s13045-021-01041-1
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen,Jiong
Affiliation1.State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products,Ningbo University,Ningbo,315211,China
2.Laboratory of Biochemistry and Molecular Biology,School of Marine Sciences,Ningbo University,Ningbo,315211,China
3.Key Laboratory of Applied Marine Biotechnology of Ministry of Education,Ningbo University,Ningbo,315211,China
4.Institute of Chinese Medical Sciences,State Key Laboratory of Quality Research in Chinese Medicine,University of Macau,Macao
5.Department of Immunology and Medical Microbiology,Nanjing University of Chinese Medicine,Nanjing,210046,China
6.Department of Chemistry,Hong Kong Baptist University,Kowloon,999077,Hong Kong
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang,Guan Jun,Zhu,Ming Hui,Lu,Xin Jiang,et al. The emerging role of KDM5A in human cancer[J]. Journal of Hematology and Oncology,2021,14(1).
APA Yang,Guan Jun,Zhu,Ming Hui,Lu,Xin Jiang,Liu,Yan Jun,Lu,Jian Fei,Leung,Chung Hang,Ma,Dik Lung,&Chen,Jiong.(2021).The emerging role of KDM5A in human cancer.Journal of Hematology and Oncology,14(1).
MLA Yang,Guan Jun,et al."The emerging role of KDM5A in human cancer".Journal of Hematology and Oncology 14.1(2021).
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