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Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice
Hu,Wei Hui1,2,3; Mak,Shing Hung1,2; Zheng,Zhong Yu1,2; Xia,Ying Jie1,2; Xu,Miranda Li1,2; Duan,Ran1,2,3; Dong,Tina Ting Xia1,2,3; Li,Shao Ping4; Zhan,Chang Sen5,6; Shang,Xiao Hui5,6; Tsim,Karl Wah Keung1,2,3
2020-07-14
Source PublicationFrontiers in Pharmacology
Volume11
AbstractBackground: Shexiang Baoxin Pill (SBP), a formulated traditional Chinese medicine (TCM), has been widely used to treat cardiovascular diseases for years. This herbal mixture has been shown to promote differentiation of cultured neuronal cells. Here, we aimed to investigate the effects of SBP in attenuating cognitive impairment in APP/PS1 transgenic mice. Methods: Ethanol and water extracts of SBP, denoted as SBP and SBP, were standardized and applied onto cultured rat pheochromocytoma PC12 cells. The potential effect of SBP extract in attenuating the cognitive impairments in APP/PS1 transgenic mice was shown by following lines of evidence: (i) inhibition of Aβ fibril formation, (ii) suppression of secretions of cytokines, and (iii) improvement of behavioral tests by Morris water maze. Results: SBP and SBP inhibited the formation of β-amyloid fibrils and protected the Aβ-induced cytotoxicity in cultured PC12 cells. In APP/PS1 transgenic mice, the treatment of SBP inhibited expressions of NO, NOS, AChE, as well as aggregation of Aβ. Besides, the levels of pro-inflammatory cytokines were suppressed by SBP treatment in the transgenic mice. Importantly, the behavioral tests by Morris Water maze indicated that SBP attenuated cognitive impairments in APP/PS1 transgenic mice. Conclusion: The current result has supported the notion that SPB might ameliorate the cognitive impairment through multiple targets, suggesting that SBP could be considered as a promising anti-AD agent.
Keywordacetylcholinesterase Alzheimer’s disease Chinese medicine cognitive enhancing effect neuroprotective Shexiang Baoxin Pill
DOI10.3389/fphar.2020.01045
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Shenzhen Key Laboratory of Edible and Medicinal Bioresources,HKUST Shenzhen Research Institute,Shenzhen,China
2.Division of Life Science and Center for Chinese Medicine and State Key Laboratory of Molecular Neuroscience,The Hong Kong University of Science and Technology,Hong Kong
3.Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation,College of Marine Sciences,South China Agricultural University,Guangzhou,China
4.Institute of Chinese Medical Sciences,University of Macau,Macao
5.Shanghai Engineering Research Center for Innovation of Solid Preparation of TCM,Shanghai,China
6.Shanghai Hutchison Pharmaceuticals Ltd,Shanghai,China
Recommended Citation
GB/T 7714
Hu,Wei Hui,Mak,Shing Hung,Zheng,Zhong Yu,et al. Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice[J]. Frontiers in Pharmacology,2020,11.
APA Hu,Wei Hui,Mak,Shing Hung,Zheng,Zhong Yu,Xia,Ying Jie,Xu,Miranda Li,Duan,Ran,Dong,Tina Ting Xia,Li,Shao Ping,Zhan,Chang Sen,Shang,Xiao Hui,&Tsim,Karl Wah Keung.(2020).Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice.Frontiers in Pharmacology,11.
MLA Hu,Wei Hui,et al."Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice".Frontiers in Pharmacology 11(2020).
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