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Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza
Liu,Mei Ting; Zhao,Jing; Li,Shao Ping
2021-01-25
Source PublicationJournal of Chromatography A
ISSN0021-9673
Volume1637
Abstract

In this work, a smartphone-based device was constructed for thin-layer chromatography (TLC) detection and semi-quantitative analysis of the components of Salvia miltiorrhiza. The key construction and shooting parameters were investigated by the relative peak area and signal-to-noise ratio. The best conditions were as follows: shooting height, 17 cm; angle between the UV lamp and TLC plate, 58°; exposure compensation, 0~0.2 EV; and shutter speed under daylight and UV 365 nm, 1/50 s and 1/5 s, respectively. These ideal conditions could be replicated by smartphones from different brands with different versions of software. With good precision, repeatability and stability, the developed device was used for the semi-quantitative analysis of salvianolic acid B, rosmarinic acid, cryptotanshinone, tanshinone I, tanshinone IIA, and miltirone in the TLC analysis of 10 batches of S. miltiorrhiza. The results were compared with those obtained by a TLC densitometric scanner and two common types of image processing software, i.e., Gelanalyzer and ImageJ. Except for salvianolic acid B in the TLC densitometric scanner, all results were not significantly different among these methods, which suggested that smartphones might be a useful tool for the quality control of traditional Chinese medicines.

KeywordQuality Control Salvia Miltiorrhiza Smartphone Tlc Traditional Chinese Medicines (Tcms)
DOI10.1016/j.chroma.2020.461826
URLView the original
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemical Research Methods ; Chemistry, Analytical
WOS IDWOS:000616104700002
Scopus ID2-s2.0-85098570643
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorZhao,Jing; Li,Shao Ping
AffiliationState Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macau,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu,Mei Ting,Zhao,Jing,Li,Shao Ping. Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza[J]. Journal of Chromatography A,2021,1637.
APA Liu,Mei Ting,Zhao,Jing,&Li,Shao Ping.(2021).Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza.Journal of Chromatography A,1637.
MLA Liu,Mei Ting,et al."Application of smartphone in detection of thin-layer chromatography: Case of salvia miltiorrhiza".Journal of Chromatography A 1637(2021).
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