Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions
Yan,Fenggen1; Zhang,Jing1; Li,Xiong1; Mo,Xiumei1; Liu,Junfeng1; Ye,Siqi1; Lin,Ying1; Qiu,Xiaohui1; Lee,Simon Mingyuen2; Chen,Dacan1
Source PublicationEvidence-based Complementary and Alternative Medicine
AbstractAtopic dermatitis (AD), also known as atopic eczema, is a chronic pruritic inflammatory skin disease. The available systemic therapies for atopic dermatitis are inadequate. Objective. This study aimed to evaluate the effects of the Chinese herbal formula Pei Tu Qing Xin (PTQX) on dermatitis severity and ear swelling, immunomodulation, and the infiltration of mast cells in a mouse model of 1-chloro-2,4-dinitrobenzene- (DNCB-) induced AD. Methods. AD-like symptoms were induced by DNCB in NC/Nga mice. Skin lesions, dermatitis, ear swelling, and scratching behaviour were evaluated. Changes in the T-helper type 1 (Th1), Th2, Th17, and regulatory T (Treg) subtypes and immunoregulation in the spleen and lymph nodes were detected by flow cytometry. Results. Histopathological and immunohistochemical analyses demonstrated that PTQX decreased the DNCB-mediated induction of mast cells and infiltration of inflammatory cells in the ear and dorsal skin. PTQX also reduced the DNCB-induced increase in the serum immunoglobulin E level, pruritus, and dermatitis (red, flaky areas) on the dorsal skin. Furthermore, PTQX regulated the balance between the populations of Th1, Th2, Th17, and Treg cells (particularly the latter two) in the lymph nodes. Conclusions. Our results suggest that the Chinese herbal formula PTQX can alleviate symptoms of AD, such as epithelial damage, redness, swelling, and pruritus, and potentially be used to treat this condition.
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Scopus ID2-s2.0-85076916683
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen,Dacan
Affiliation1.Department of Dermatology,Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangdong Provincial Hospital of Chinese Medicine,Guangdong Prov. Key Lab. of Chinese Med. for Prevention and Treatment of Refractory Chronic Diseases,Guangzhou, Guangdong,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
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Yan,Fenggen,Zhang,Jing,Li,Xiong,et al. Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions[J]. Evidence-based Complementary and Alternative Medicine,2019,2019.
APA Yan,Fenggen,Zhang,Jing,Li,Xiong,Mo,Xiumei,Liu,Junfeng,Ye,Siqi,Lin,Ying,Qiu,Xiaohui,Lee,Simon Mingyuen,&Chen,Dacan.(2019).Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions.Evidence-based Complementary and Alternative Medicine,2019.
MLA Yan,Fenggen,et al."Therapeutic Effects of Chinese Herbal Formula (PTQX) on NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions".Evidence-based Complementary and Alternative Medicine 2019(2019).
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