UM
Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model
Chi,Liandi1; Khan,Imran2; Lin,Zibei1; Zhang,Jiwen3,4; Lee,M. Y.Simon1; Leong,Waikit2; Hsiao,W. L.Wendy2; Zheng,Ying1
2020-02-01
Source PublicationPhytomedicine
ISSN0944-7113
Volume67
AbstractBackground: Inulin-type fructo-oligosaccharides (FOSs) purified from Morinda officinalis How., an effective oral antidepressant for mild to moderate depression, have a largely unknown efficacy and poor bioavailability. Purpose: Therefore, the microbiota-gut-brain axis was used to investigate the antidepressive properties of FOSs at the interface of the gut microbiota (GM). Study design and methods: FOSs was introduced via intragastric gavage to rats exposed to chronic unpredictable mild stress (CUMS), and the antidepressive effects were investigated through behavioral tests, intestinal morphology and corticosterone levels. Bacterial genomic DNA was extracted from feces, and the GM was profiled for using enterobacterial repetitive intergenic consensus (ERIC)-PCR analysis, partial least squares-discriminant analysis (PLS-DA) and 16S rRNA gene pyrosequencing. Results: It was observed that FOSs alleviated depression-like behaviors and repaired intestinal epithelia damages. FOSs treatment lowered corticosterone levels in the plasma and urine of the model rats. Moreover, the GM compositions of normal and model rats were distantly clustered and were mainly related to the disappearance of beneficial bacteria (e.g., Acinetobacter, Barnesiella, Coprococcus, Dialister, Lactobacillus, and Paenibacillus) and appearance of depression-associated bacteria (e.g., Anaerostipes, Oscillibacter, Proteobacteria, and Streptococcus) in depressive rats. Interestingly, the dysbiosis in depressive rats’ gut was reinstated with FOSs treatments. Notably, FOSs promoted the abundance of the bacterial phylum Cyanobacteria, a group of bacteria known for the secretion of pharmacologically important metabolites, such as HS, that exhibit antidepressant-like properties. Apparently, FOSs-induced modulation of GM was more antidepressive compared to a component of FOSs, degrees of polymerization (DP) 5, and fluoxetine, the standard antidepressant drug. Conclusion: In conclusion, this study implied that antidepressant efficacy of FOSs was inseparable from and strongly associated with the modulation of the host’ s GM.
KeywordBehavioral tests Chronic unpredictable mild stress (CUMS) Gut microbiota Inulin-type fructo-oligosaccharides (FOSs)
DOI10.1016/j.phymed.2019.153157
URLView the original
Language英语
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,Macao
2.State Key Laboratory of Quality Research in Chinese Medicine,Macau University of Science and Technology,Macao,Macao
3.Center for Drug Delivery System,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China
4.NMPA Key Laboratory for Quality Research and Evaluation of Pharmaceutical Excipients,China
First Author AffilicationInstitute of Chinese Medical Sciences
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Chi,Liandi,Khan,Imran,Lin,Zibei,et al. Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model[J]. Phytomedicine,2020,67.
APA Chi,Liandi,Khan,Imran,Lin,Zibei,Zhang,Jiwen,Lee,M. Y.Simon,Leong,Waikit,Hsiao,W. L.Wendy,&Zheng,Ying.(2020).Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model.Phytomedicine,67.
MLA Chi,Liandi,et al."Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model".Phytomedicine 67(2020).
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