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Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery
Gao,Cheng1; Cheng,Qian1; Wei,Jianwen1,2; Sun,Chen1; Lu,Siyu3; Kwong,Cheryl H.T.1; Lee,Simon M.Y.1; Zhong,Zhiyuan2; Wang,Ruibing1
Source PublicationMaterials Today

Cells possess inherent advantages to facilitate targeted payload delivery. Current strategies to conjugate payload carriers to the surface of cells are either via covalent bonds that not only involve complicated synthetic process but also often impair cellular functions, or via biological ligand-receptor interactions that are only specific to particular types of cells. Herein, we report a facile, bioorthogonal supramolecular conjugation strategy to prepare targeted cell-hitchhiking delivery systems, mediated via artificial host–guest interactions between β-cyclodextrin and adamantane, respectively anchored (via insertion) on the surfaces of live cells and payload carriers. In a paw swelling inflammation mouse model, supramolecularly conjugated macrophage-carriers (either cell–cell or cell-nanoparticle systems) were efficiently delivered hand-in-hand to the swelling paw, driven by the inflammatory tropism of macrophage. Furthermore, in an acute lung inflammation model of mouse, supramolecular conjugation of peritoneal macrophage and quercetin-loaded liposomes significantly improved targeting efficiency of the liposomes, and effectively alleviated the lung inflammation through the anti-inflammatory and anti-oxidative effects of quercetin. The cell-friendly, facile, host–guest interactions mediated cellular conjugation may provide the very first general strategy for preparing various cell-hitchhiking delivery systems to meet the needs of diverse biomedical applications.

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Indexed BySCIE
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000596583700001
Scopus ID2-s2.0-85088101305
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhong,Zhiyuan; Wang,Ruibing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,China
2.Biomedical Polymers Laboratory,College of Chemistry,Chemical Engineering and Materials Science and State Key Laboratory of Radiation Medicine and Protection,Soochow University,Suzhou,215123,China
3.Green Catalysis Center,College of Chemistry,Zhengzhou University,Zhengzhou,100 Kexue Road,450001,China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Gao,Cheng,Cheng,Qian,Wei,Jianwen,et al. Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery[J]. Materials Today,2020,40:9-17.
APA Gao,Cheng,Cheng,Qian,Wei,Jianwen,Sun,Chen,Lu,Siyu,Kwong,Cheryl H.T.,Lee,Simon M.Y.,Zhong,Zhiyuan,&Wang,Ruibing.(2020).Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery.Materials Today,40,9-17.
MLA Gao,Cheng,et al."Bioorthogonal supramolecular cell-conjugation for targeted hitchhiking drug delivery".Materials Today 40(2020):9-17.
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