UM
Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor-An Opportunity for Cancer Treatment
Al-Hatamleh,Mohammad A.I.1; E A R,Engku Nur Syafirah2; Boer,Jennifer C.3; Ferji,Khalid4; Six,Jean Luc4; Chen,Xin5; Elkord,Eyad6; Plebanski,Magdalena3; Mohamud,Rohimah1,7
2019-12-20
Source PublicationCells
Volume9Issue:1
AbstractTumor necrosis factor receptor 2 (TNFR2) is expressed on some tumor cells, such as myeloma, Hodgkin lymphoma, colon cancer and ovarian cancer, as well as immunosuppressive cells. There is increasingly evidence that TNFR2 expression in cancer microenvironment has significant implications in cancer progression, metastasis and immune evasion. Although nanomedicine has been extensively studied as a carrier of cancer immunotherapeutic agents, no study to date has investigated TNFR2-targeting nanomedicine in cancer treatment. From an epigenetic perspective, previous studies indicate that DNA demethylation might be responsible for high expressions of TNFR2 in cancer models. This perspective review discusses a novel therapeutic strategy based on nanomedicine that has the capacity to target TNFR2 along with inhibition of DNA demethylation. This approach may maximize the anti-cancer potential of nanomedicine-based immunotherapy and, consequently, markedly improve the outcomes of the management of patients with malignancy.
Keywordimmunosuppressive immunotherapy nanoparticles regulatory T cells TNF
DOI10.3390/cells9010033
URLView the original
Language英语
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Department of Immunology,School of Medical Sciences,Universiti Sains Malaysia,16150,Malaysia
2.Department of Medical Microbiology and Parasitology,School of Medical Sciences,Universiti Sains Malaysia,16150,Malaysia
3.Translational Immunology and Nanotechnology Unit,School of Health and Biomedical Sciences,RMIT University,Australia
4.CNRS,LCPM,F-5400 Nancy,Université de Lorraine,France
5.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences. University of Macau,999078,China
6.Cancer Research Center,Qatar Biomedical Research Institute,Hamad Bin Khalifa University,Doha,Qatar Foundation,34110,Qatar
7.Hospital Universiti Sains Malaysia,Universiti Sains Malaysia,16150,Malaysia
Recommended Citation
GB/T 7714
Al-Hatamleh,Mohammad A.I.,E A R,Engku Nur Syafirah,Boer,Jennifer C.,et al. Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor-An Opportunity for Cancer Treatment[J]. Cells,2019,9(1).
APA Al-Hatamleh,Mohammad A.I.,E A R,Engku Nur Syafirah,Boer,Jennifer C.,Ferji,Khalid,Six,Jean Luc,Chen,Xin,Elkord,Eyad,Plebanski,Magdalena,&Mohamud,Rohimah.(2019).Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor-An Opportunity for Cancer Treatment.Cells,9(1).
MLA Al-Hatamleh,Mohammad A.I.,et al."Synergistic Effects of Nanomedicine Targeting TNFR2 and DNA Demethylation Inhibitor-An Opportunity for Cancer Treatment".Cells 9.1(2019).
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