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A profile of TNFR2+ regulatory T cells and CD103+ dendritic cells in the peripheral blood of patients with asthma
Azid,Nor Azrini1; Ahmad,Suhana1; Boer,Jennifer C.2; Al-Hatamleh,Mohammad A.I.1; Mohammad,Nurashikin3,4; Mohd Ashari,Noor Suryani1,4; Tan,Hern Tze1,4; Chen,Xin5; Plebanski,Magdalena2; Mohamud,Rohimah1,4
2020-10-01
Source PublicationHuman Immunology
ISSN0198-8859
Volume81Issue:10-11Pages:634-643
AbstractThe interaction of tolerogenic CD103 dendritic cells (DCs) with regulatory T (Tregs) cells modulates immune responses by inducing immune tolerance. Hence, we determined the proportion of these cells in the peripheral blood mononuclear cells (PBMC) of asthmatic patients. We observed lower trends of CD11bCD103 DCs and CD86 within CD11bCD103 DCs, while increased levels of Foxp3 expressing CD25TNFR2 cells in asthmatics. There was a positive correlation in the expression of Foxp3 within CD3CD4CD25TNFR2 Tregs and CD11bCD103 as well as the expression of CD86 within HLA-DRCD11cCD11bCD103 DCs. In conclusion, we suggest that the increased levels of Tregs in blood could continuously suppress the T helper 2 (Th2) cells activation in the circulation which is also supported by the increase of anti-inflammatory cytokines IL-10 and TNF. Overall, functional immunoregulation of the regulatory cells, particularly Tregs, exhibit immune suppression and induce immune tolerance linked with the immune activation by the antigen presenting cells (APC).
KeywordAsthma CD103 Dendritic cells Tregs Tumor necrosis factor receptor 2 (TNFR2)
DOI10.1016/j.humimm.2020.07.006
URLView the original
Language英语
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorMohamud,Rohimah
Affiliation1.Department of Immunology,School of Medical Sciences,Universiti Sains Malaysia,Kelantan,Malaysia
2.Translational Immunology and Nanotechnology Unit,School of Health and Biomedical Sciences,RMIT University,Bundoora,3083,Australia
3.Department of Internal Medicine,School of Medical Sciences,Universiti Sains Malaysia,Kelantan,Malaysia
4.Hospital Universiti Sains Malaysia,Universiti Sains Malaysia,Kelantan,Malaysia
5.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,China
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GB/T 7714
Azid,Nor Azrini,Ahmad,Suhana,Boer,Jennifer C.,et al. A profile of TNFR2+ regulatory T cells and CD103+ dendritic cells in the peripheral blood of patients with asthma[J]. Human Immunology,2020,81(10-11):634-643.
APA Azid,Nor Azrini,Ahmad,Suhana,Boer,Jennifer C.,Al-Hatamleh,Mohammad A.I.,Mohammad,Nurashikin,Mohd Ashari,Noor Suryani,Tan,Hern Tze,Chen,Xin,Plebanski,Magdalena,&Mohamud,Rohimah.(2020).A profile of TNFR2+ regulatory T cells and CD103+ dendritic cells in the peripheral blood of patients with asthma.Human Immunology,81(10-11),634-643.
MLA Azid,Nor Azrini,et al."A profile of TNFR2+ regulatory T cells and CD103+ dendritic cells in the peripheral blood of patients with asthma".Human Immunology 81.10-11(2020):634-643.
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