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Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging
Couto,Tania Alexandra1,2; Xu,Shiyang1,2; Da Silva,Paulo Armada3; Wu,Chenggang1,4,5; Neergaard,Karl1; Wang,Meng Yun1,2; Zhang,Juan1,3; Xiang,Yutao1,3; Yuan,Zhen1,2
2020
Source PublicationNeural Plasticity
ISSN2090-5904
Volume2020
Abstract

The current study is aimed at establishing links between brain network examination and neural plasticity studies measured by optical neuroimaging. Sixteen healthy subjects were recruited from the University of Macau to test the Granger Prediction Estimation (GPE) method to investigate brain network connectivity during figurative language comprehension. The method is aimed at mapping significant causal relationships across language brain networks, captured by functional near-infrared spectroscopy measurements (fNIRS): (i) definition of regions of interest (ROIs) based on significant channels extracted from spatial activation maps; (ii) inspection of significant causal relationships in temporal resolution, exploring the experimental task agreement; and (iii) early identification of stronger causal relationships that guide neuromodulation intervention, targeting impaired connectivity pathways. Our results propose top-down mechanisms responsible for perceptive-attention engagement in the left anterior frontal cortex and bottom-up mechanism in the right hemispheres during the semantic integration of figurative language. Moreover, the interhemispheric directional flow suggests a right hemisphere engagement in decoding unfamiliar literal sentences and fine-grained integration guided by the left hemisphere to reduce ambiguity in meaningless words. Finally, bottom-up mechanisms seem activated by logographic-semantic processing in literal meanings and memory storage centres in meaningless comprehension. To sum up, our main findings reveal that the Granger Prediction Estimation (GPE) integrated strategy proposes an effective link between assessment and intervention, capable of enhancing the efficiency of the treatment in language disorders and reducing the neuromodulation side effects.

DOI10.1155/2020/8882207
URLView the original
Indexed BySCIE ; SSCI
Language英語English
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000585093700001
Scopus ID2-s2.0-85094222335
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYuan,Zhen
Affiliation1.Centre for Cognitive and Brain Sciences,University of Macau,Macau S.A.R.,Macao
2.Faculty of Health Sciences,University of Macau,Macau S.A.R.,Macao
3.Faculty of Human Kinetics,University of Lisbon,Lisbon,Portugal
4.Faculty of Education,University of Macau,Macau S.A.R.,Macao
5.School of Education,Shanghai International Studies University,Shanghai,China
First Author AffilicationUniversity of Macau;  Faculty of Health Sciences
Corresponding Author AffilicationUniversity of Macau;  Faculty of Health Sciences
Recommended Citation
GB/T 7714
Couto,Tania Alexandra,Xu,Shiyang,Da Silva,Paulo Armada,et al. Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging[J]. Neural Plasticity,2020,2020.
APA Couto,Tania Alexandra,Xu,Shiyang,Da Silva,Paulo Armada,Wu,Chenggang,Neergaard,Karl,Wang,Meng Yun,Zhang,Juan,Xiang,Yutao,&Yuan,Zhen.(2020).Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging.Neural Plasticity,2020.
MLA Couto,Tania Alexandra,et al."Effective Connectivity Study Guiding the Neuromodulation Intervention in Figurative Language Comprehension Using Optical Neuroimaging".Neural Plasticity 2020(2020).
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