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The efficacy of guanxinning injection in treating angina pectoris: Systematic review and meta-analysis of randomized controlled trials
Jia,Yongliang1; Leung,Siu Wai1,2; Lee,Ming Yuen1; Cui,Guozhen1; Huang,Xiaohui1; Pan,Fongha1
2013
Source PublicationEvidence-based Complementary and Alternative Medicine
ISSN1741-427X
Volume2013
AbstractObjective. The randomized controlled trials (RCTs) on Guanxinning injection (GXN) in treating angina pectoris were published only in Chinese and have not been systematically reviewed. This study aims to provide a PRISMA-compliant and internationally accessible systematic review to evaluate the efficacy of GXN in treating angina pectoris. Methods. The RCTs were included according to prespecified eligibility criteria. Meta-analysis was performed to evaluate the symptomatic (SYMPTOMS) and electrocardiographic (ECG) improvements after treatment. Odds ratios (ORs) were used to measure effect sizes. Subgroup analysis, sensitivity analysis, and metaregression were conducted to evaluate the robustness of the results. Results. Sixty-five RCTs published between 2002 and 2012 with 6064 participants were included. Overall ORs comparing GXN with other drugs were 3.32 (95% CI: [2.72, 4.04]) in SYMPTOMS and 2.59 (95% CI: [2.14, 3.15]) in ECG. Subgroup analysis, sensitivity analysis, and metaregression found no statistically significant dependence of overall ORs upon specific study characteristics. Conclusion. This meta-analysis of eligible RCTs provides evidence that GXN is effective in treating angina pectoris. This evidence warrants further RCTs of higher quality, longer follow-up periods, larger sample sizes, and multicentres/multicountries for more extensive subgroup, sensitivity, and metaregression analyses. © 2013 Yongliang Jia et al.
DOI10.1155/2013/282707
URLView the original
Language英语
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao
2.School of Informatics,University of Edinburgh,Edinburgh EH8 9AB,United Kingdom
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Jia,Yongliang,Leung,Siu Wai,Lee,Ming Yuen,et al. The efficacy of guanxinning injection in treating angina pectoris: Systematic review and meta-analysis of randomized controlled trials[J]. Evidence-based Complementary and Alternative Medicine,2013,2013.
APA Jia,Yongliang,Leung,Siu Wai,Lee,Ming Yuen,Cui,Guozhen,Huang,Xiaohui,&Pan,Fongha.(2013).The efficacy of guanxinning injection in treating angina pectoris: Systematic review and meta-analysis of randomized controlled trials.Evidence-based Complementary and Alternative Medicine,2013.
MLA Jia,Yongliang,et al."The efficacy of guanxinning injection in treating angina pectoris: Systematic review and meta-analysis of randomized controlled trials".Evidence-based Complementary and Alternative Medicine 2013(2013).
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