UM
Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study
Li Haibin1,2; Wang Anxin3; Qi Gao1,2; Guo Jin4; Li Xia5; Wang Wei6; Xiang Yutao7; Guo Xiuhua1,2
2019-03
Source PublicationPsychiatry Research
ISSN0165-1781
Volume273Pages:75-81
Abstract

The association between cystatin C and depressive symptoms in the general population has not been thoroughly elucidated to date. We investigated the association of cystatin C with new-onset depressive symptoms among individuals with normal creatinine-based estimated glomerular filtration rates (eGFR). In the China Health and Retirement Longitudinal Study, 5111 participants without depressive symptoms or renal dysfunction (eGFR < 60 ml/min/1.73 m2) were included. The outcome was new-onset depressive symptoms over 4 years, defined as a score of ≥12 on the 10-item Center for Epidemiologic Studies Depressive Symptoms Scale. The incidence risk ratio (IRR) and 95% confidence interval (CI) were calculated using modified Poisson regression models. During a 4-year follow-up period, 1746 (34.16%) incidents of depressive symptoms occurred. In a multivariable-adjusted model, the risk of incident depressive symptoms was 1.07 (95% CI 1.02–1.11) per-SD change in cystatin C. A greater cystatin C level was associated with a higher risk of new-onset depressive symptoms among subjects with relatively normal renal function.

KeywordCystatin c Renal Function Depressive Symptoms Elderly
DOI10.1016/j.psychres.2019.01.009
Indexed BySSCI
Language英語English
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000465059400011
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorGuo Xiuhua
Affiliation1.Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China
2.Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China
3.Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
4.Guanghua Group Pty Ltd, Melbourne, Victoria, Australia
5.Department of Mathematics and Statistics, La Trobe University, Melbourne, Victoria, Australia
6.Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Western Australia, Australia
7.Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macao SAR, China
Recommended Citation
GB/T 7714
Li Haibin,Wang Anxin,Qi Gao,et al. Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study[J]. Psychiatry Research,2019,273:75-81.
APA Li Haibin,Wang Anxin,Qi Gao,Guo Jin,Li Xia,Wang Wei,Xiang Yutao,&Guo Xiuhua.(2019).Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study.Psychiatry Research,273,75-81.
MLA Li Haibin,et al."Cystatin C and risk of new-onset depressive symptoms among individuals with a normal creatinine-based estimated glomerular filtration rate: A prospective cohort study".Psychiatry Research 273(2019):75-81.
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