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Chemical composition, antioxidant and anti-tyrosinase activities of fractions from Stenoloma chusanum
Wu, Siqi1; Li, Jing1; Wang, Quanxi1,2; Cao, Jianguo1; Yu, Hua3; Cao, Hui3; Xiao, Jianbo1
Conference NameInternational Conference on Industrial Crops - Promoting Sustainability / 28th Annual Meeting of the Association-for-the-Advancement-of-Industrial-Crops (AAIC)
Conference DateSEP, 2016
Conference PlaceRochester, NY
Publication PlacePO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS

Stenoloma chusanum is a traditional Chinese medicine with very high total flavonoid content (TFC) and the total phenolic content (TPC). To explore its phytochemicals and potential in therapeutic applications, the antioxidant activity and tyrosinase inhibitory activity of S. chusanum fractions prepared by extraction with petroleum ether (PF), chloroform (CF), ethyl acetate (EF), n-butanol (NF) and water fractions (WF) as well as their flavonoid profiles were investigated. All these five fractions contained appreciable quantities of flavonoids and phenols, but the EF fraction was richest one with TPC and TFC values of 385.5 mg gallic acid equivalents/g and 746.8 mg rutin equivalents/g, respectively. The EF, NF, and CF fractions showed significant antioxidant activity, presumably due to their high flavonoid and phenol contents. All five fractions also caused dose-dependent inhibition of tyrosinase activity, and the PF fraction was a stronger inhibitor than the positive control inhibitor arbutin. However, the compounds responsible for this activity are currently unknown. These fractions' chemical profiles were analyzed by LC/MS, revealing that their most abundant secondary metabolites were flavonoids and alkaloids. The EF and NF fractions contained similar compounds, including flavonols, flavones, isoquinolines, filicinic acid, and gigantecine. Further work on S. chusanum to isolate these compounds and explain the mechanisms responsible for their antioxidant activity and anti-tyrosinase activity is warranted.

KeywordStenoloma Chusanum Total Flavonoid And Phenol Antioxidant Activity Anti-tyrosinase Activity
URLView the original
Indexed BySCI ; CPCI
WOS Research AreaAgriculture
WOS SubjectAgricultural Engineering ; Agronomy
WOS IDWOS:000412963900063
The Source to ArticleWOS
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionInstitute of Chinese Medical Sciences
Affiliation1.College of Life and Environment Sciences, Shanghai Normal University, Shanghai 200234, China
2.Shanghai Key Laboratory of Plant Functional Genomics and Resource, Shanghai Chenshan Botanical Garden, Shanghai 201602, China
3.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macau
Recommended Citation
GB/T 7714
Wu, Siqi,Li, Jing,Wang, Quanxi,et al. Chemical composition, antioxidant and anti-tyrosinase activities of fractions from Stenoloma chusanum[C]. PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS:ELSEVIER SCIENCE BV,2017:539-545.
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