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New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging
Chien‐Wei Lee1; Pei‐Chun Wu2; I‐Ling Hsu1; Tzu‐Ming Liu2; Wai‐How Chong2; Cheng‐Ham Wu3; Tsung‐Yuan Hsieh3; Lun‐Zhang Guo3; Yu Tsao4; Po‐Ting Wu5; Jiashing Yu5; Pei‐Jane Tsai6; Huei‐Sheng Huang6; Yu‐Chun Chuang7; Chih‐Chia Huang1
2019-05
Source PublicationSMALL
ISSN1613-6810
Volume15Issue:20
Abstract

Emerging advances in iron oxide nanoparticles exploit their high magnetization for various applications, such as bioseparation, hyperthermia, and magnetic resonance imaging. In contrast to their excellent magnetic performance, the harmonic generation and luminescence properties of iron oxide nanoparticles have not been thoroughly explored, thus limiting their development as a tool in photomedicine. In this work, a seed/growth‐inspired synthesis is developed combined with primary mineralization and a ligand‐assisted secondary growth strategy to prepare mesostructured α‐FeOOH nanorods (NRs). The sub‐wavelength heterogeneity of the refractive index leads to enhanced third‐harmonic generation (THG) signals under near‐infrared excited wavelengths at 1230 nm. The as‐prepared NRs exhibit an 11‐fold stronger THG intensity compared to bare α‐FeOOH NRs. Using these unique nonlinear optical properties, it is demonstrated that mesostructured α‐FeOOH NRs can serve as biocompatible and nonbleaching contrast agents in THG microscopy for long‐term labeling of cells as well as in angiography in vivo by modifying lectin to enhance the binding efficiency to the glycocalyx layers on the wall of blood vessels. These results provide a new insight into Fe‐based nanoplatforms capable of emitting coherent light as molecular probes in optical microscopy, thus establishing a complementary microscopic imaging method for macroscopic magnetic imaging systems.

KeywordMesostructured Nanorods Nonlinear Optical Ostwald Ripening Third Harmonic Generation
DOI10.1002/smll.201805086
Indexed BySCIE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000471297400001
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorTzu‐Ming Liu; Chih‐Chia Huang
Affiliation1.Department of Photonics, Center of Applied Nanomedicine, Center for Micro/Nano Science and Technology and Advanced Optoelectronic Technology Center, National Cheng Kung University, Tainan, 70101 Taiwan
2.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, 999078 China
3.Institute of Biomedical Engineering & Molecular Imaging Center, National Taiwan University, Taipei, 10617 Taiwan
4.Research Center for Information Technology Innovation, Academia Sinica, Taipei, 11529 Taiwan
5.Department of Chemical Engineering, National Taiwan University, Taipei, 10617 Taiwan
6.Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, 70101 Taiwan
7.National Synchrotron Radiation Research Center, Hsinchu, 300 Taiwan
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Chien‐Wei Lee,Pei‐Chun Wu,I‐Ling Hsu,et al. New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging[J]. SMALL,2019,15(20).
APA Chien‐Wei Lee,Pei‐Chun Wu,I‐Ling Hsu,Tzu‐Ming Liu,Wai‐How Chong,Cheng‐Ham Wu,Tsung‐Yuan Hsieh,Lun‐Zhang Guo,Yu Tsao,Po‐Ting Wu,Jiashing Yu,Pei‐Jane Tsai,Huei‐Sheng Huang,Yu‐Chun Chuang,&Chih‐Chia Huang.(2019).New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging.SMALL,15(20).
MLA Chien‐Wei Lee,et al."New Templated Ostwald Ripening Process of Mesostructured FeOOH for Third-Harmonic Generation Bioimaging".SMALL 15.20(2019).
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