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Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia
Seon-Cheol Park1; Hong Seok Oh2; Adarsh Tripathi3; Roy Abraham Kallivayalil4; Ajit Avasthi5; Sandeep Grover5; Andi Jayalangkara Tanra6; Shigenobu Kanba7; Takahiro A. Kato7; Toshiya Inada8; Kok Yoon Chee9; Mian-Yoon Chong10,11; Shih-Ku Lin12; Kang Sim13,14; Yu-Tao Xiang15; Chay Hoon Tan16; Afzal Javed17; Norman Sartorius18; Naotaka Shinfuku19; Yong Chon Park20

Background: Although cannabis use has been linked with schizophrenia in a dose–response pattern, to our knowledge, the relationship between cannabis and schizophrenia has rarely been reported in Asian population.

Aim: We compared the clinical characteristics and psychotropic prescription patterns between cannabis users and non-users among Asian patients with schizophrenia. Moreover, we aimed to identify the independent correlates of cannabis use in these subjects.

Methods: We performed the analysis of the data from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics (REAP-AP), a collaborative consortium survey used to collate the prescription patterns for antipsychotic and other psychotropic medications in patients with schizophrenia in Asia. We included 132 schizophrenia patients in the group of lifetime cannabis use and 1756 in the group that had never used cannabis. A binary logistic model was fitted to detect the clinical correlates of lifetime cannabis use.

Results: Adjusting for the effects of age, sex, geographical region, income group, duration of untreated psychosis, and Charlson comordity index level, a binary logistic regression model revealed that lifetime cannabis use was independently associated with aggressive behavior [adjusted odds ratio (aOR) = 1.582, 95% confidence interval (CI) = 1.006–2.490, p = .047] and with long-acting injectable antipsychotic treatment (aOR = 1.796, 95% CI = 1.444–2.820, p = .001).

Conclusion: Our findings indicate a close link between lifetime cannabis use and aggressive behavior. The use of long-acting, injectable antipsychotics preferentially treats the aggressive behavior cannabis users among patients with schizophrenia in Asia, especially, the South or Southeast Asia.

KeywordAggressive Behavior Asian Cannabis Long-acting Injectable Antipsychotics Schizophrenia
Indexed BySCIE
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:00477892100002
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Inje Univ, Dept Psychiat, Haeundae Paik Hosp, Busan 48108, South Korea
2.Konyang Univ Hosp, Dept Psychiat, Daejeon, South Korea
3.King Georges Med Univ, Dept Psychiat, Chowk, India
4.Pushpagiri Inst Med Sci, Tiruvalla, India
5.Post Grad Inst Med Educ & Res PGIMER, Dept Psychiat, Chandigarh, India
6.Hasanuddin Univ, Dept Psychiat, Fac Med, Makassar, Indonesia
7.Kyushu Univ, Grad Sch Med, Dept Neuropsychiat, Fukuoka, Fukuoka, Japan
8.Nagoya Univ, Grad Sch Med, Dept Psychiat & Psychobiol, Nagoya, Aichi, Japan
9.Kuala Lumpur Hosp, Tunku Abdul Rahman Inst Neurosci, Kuala Lumpur, Malaysia
10.Chang Gung Mem Hosp, Chiayi, Taiwan
11.Chang Gung Univ, Sch Med, Taoyuan, Taiwan
12.Taipei City Hosp, Psychiat Ctr, Taipei, Taiwan
13.Natl Univ Singapore, Inst Mental Hlth, West Region, Singapore, Singapore
14.Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore
15.Univ Macau, Inst Translat Med, Unit Psychiat, Fac Hlth Sci, Taipa, Macau, Peoples R China
16.Natl Univ Singapore Hosp, Dept Pharmacol, Singapore, Singapore
17.Pakistan Psychiat Res Ctr, Fountain House, Lahore, Pakistan
18.Assoc Improvement Mental Hlth Programmes, Geneva, Switzerland
19.Seinan Gakuin Univ, Sch Human Sci, Dept Social Welf, Fukuoka, Fukuoka, Japan
20.Hanyang Univ, Dept Neuropsychiat, Guri Hosp, Guri, South Korea
Recommended Citation
GB/T 7714
Seon-Cheol Park,Hong Seok Oh,Adarsh Tripathi,et al. Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia[J]. NORDIC JOURNAL OF PSYCHIATRY,2019,73(6):323-330.
APA Seon-Cheol Park,Hong Seok Oh,Adarsh Tripathi,Roy Abraham Kallivayalil,Ajit Avasthi,Sandeep Grover,Andi Jayalangkara Tanra,Shigenobu Kanba,Takahiro A. Kato,Toshiya Inada,Kok Yoon Chee,Mian-Yoon Chong,Shih-Ku Lin,Kang Sim,Yu-Tao Xiang,Chay Hoon Tan,Afzal Javed,Norman Sartorius,Naotaka Shinfuku,&Yong Chon Park.(2019).Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia.NORDIC JOURNAL OF PSYCHIATRY,73(6),323-330.
MLA Seon-Cheol Park,et al."Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia".NORDIC JOURNAL OF PSYCHIATRY 73.6(2019):323-330.
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