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Quality of Life in Schizophrenia: A Meta-Analysis of Comparative Studie
Min Dong1; Li Lu1; Ling Zhang2; Yun-Shu Zhang3; Chee H. Ng4; Gabor S. Ungvari5; Gang Li1; Xiangfei Meng6; Gang Wang2; Yu-Tao Xiang1
AbstractStudies and findings regarding the impact of schizophrenia on quality of life (QOL) has been highly variable. This meta-analysis compared QOL between schizophrenia subjects and healthy controls with a focus on standardized measures. A systematic literature search was conducted through Pubmed, PsycINFO, EMBASE, Cochrane Library and Web of Science databases. Only studies using the World Health Organization Quality of Life (WHOQOL) or its brief version or the Short Form-36 Health Survey (SF-36) were included. Fifteen case-control studies with 2195 schizophrenia subjects and 1508 healthy controls were included in this meta-analysis. The WHOQOL/WHOQOL-BREF score was significantly lower in physical health (SMD = -1.80, 95% CI: -2.31 to −1.28, P < 0.001), psychological health (SMD = -1.28, 95% CI: -1.72 to −0.83, P < 0.001), social relationships (SMD = -1.60, 95% CI: -2.05 to −1.15, P < 0.001), and environment domains (SMD = -0.98, 95% CI: -1.38 to −0.59, P < 0.001) in schizophrenia subjects compared to controls. The SF-36 score was significantly lower in both physical (SMD = -1.09, 95% CI: -1.41 to −0.76, P < 0.001 and mental health domains (SMD = -2.08, 95% CI: -3.58 to −0.59, P = 0.006) in schizophrenia subjects than in controls. Subgroup and meta-regression analyses found that age, male gender, illness duration and income have significant moderating effects on QOL. The meta-analysis of studies with standardized measures confirmed that QOL in schizophrenia subjects is significantly lower than healthy controls. Effective interventions should be developed to improve QOL for this population.
KeywordSchizophrenia Quality Of Life Meta-analysis
Indexed BySCIE
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000481788300005
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China
2.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
3.Department of Sleep Medicine, Hebei Psychiatric Hospital, Baoding, Hebei Province, China
4.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
5.University of Notre Dame Australia, & Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Australia
6.Department of Psychiatry, McGill University and the Douglas Mental Health University Institute, Montreal, Canada
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Min Dong,Li Lu,Ling Zhang,et al. Quality of Life in Schizophrenia: A Meta-Analysis of Comparative Studie[J]. PSYCHIATRIC QUARTERLY,2019,90(3):519-532.
APA Min Dong,Li Lu,Ling Zhang,Yun-Shu Zhang,Chee H. Ng,Gabor S. Ungvari,Gang Li,Xiangfei Meng,Gang Wang,&Yu-Tao Xiang.(2019).Quality of Life in Schizophrenia: A Meta-Analysis of Comparative Studie.PSYCHIATRIC QUARTERLY,90(3),519-532.
MLA Min Dong,et al."Quality of Life in Schizophrenia: A Meta-Analysis of Comparative Studie".PSYCHIATRIC QUARTERLY 90.3(2019):519-532.
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