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Prospective memory in schizophrenia: A meta-analysis of comparative studies
Fu-Chun Zhou1; Wei Zheng2; Li Lu3; Yuan-Yuan Wang3,4; Chee H. Ng5; Gabor S. Ungvari6,7; Jun Li8; Yu-Tao Xiang3
AbstractBackground Impairment of prospective memory (PM) in schizophrenia has gained increasing attention. This meta-analysis systematically examined PM impairment in schizophrenia. Methods Both English (PubMed, PsycINFO, EMBASE, and Cochrane Library) and Chinese (WanFang, Chinese Biomedical and China Journal Net databases) databases were systematically searched from their inception until August 14, 2017. Case-control studies of PM in schizophrenia were included. Standardized mean differences (SMDs) and their 95% confidence interval (CI) were calculated using the random-effects model. Results Twenty-nine case-control studies (n = 2492) were included in the analyses. The overall and three subtypes of PM were compared between patients with schizophrenia (n = 1284) and healthy controls (n = 1208). Compared to healthy controls, patients performed significantly poorer in overall (SMD = −1.125), time-based (SMD = −1.155), event-based (SMD = −1.068), and activity-based PM (SMD = -0.563). Subgroup analyses revealed significant differences between older and younger patients (SMD = -1.398 vs. -0.763), higher male predominance and no sex predominance (SMD = -1.679 vs. -0.800), lower and higher education level (SMD = -1.373 vs.-0.637), chronic and first-episode patients (SMD = -1.237 vs. -0.641) and between eco-valid and dual-task laboratory measurements (SMD = -1.542 vs. -0.725) regarding overall PM. Meta-regression analysis showed that higher negative symptom score was significantly associated with more severe overall PM impairment in patients (P = 0.022). Conclusions In this meta-analysis the overall PM and all its subtypes, particularly the time-based PM, were significantly impaired in schizophrenia.
KeywordSchizophrenia Prospective Memory Cognitive Impairment Meta-analysis
Indexed BySCIE
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000489616900010
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
2.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China
3.Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao SAR, China
4.Faculty of Health and Life Sciences, De Montfort University, Leicester, United Kingdom
5.Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia
6.The University of Notre Dame Australia, Fremantle, Australia
7.Division of Psychiatry, School of Medicine, University of Western Australia, Perth, Australia
8.State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, China
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GB/T 7714
Fu-Chun Zhou,Wei Zheng,Li Lu,et al. Prospective memory in schizophrenia: A meta-analysis of comparative studies[J]. SCHIZOPHRENIA RESEARCH,2019,212:62-71.
APA Fu-Chun Zhou,Wei Zheng,Li Lu,Yuan-Yuan Wang,Chee H. Ng,Gabor S. Ungvari,Jun Li,&Yu-Tao Xiang.(2019).Prospective memory in schizophrenia: A meta-analysis of comparative studies.SCHIZOPHRENIA RESEARCH,212,62-71.
MLA Fu-Chun Zhou,et al."Prospective memory in schizophrenia: A meta-analysis of comparative studies".SCHIZOPHRENIA RESEARCH 212(2019):62-71.
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