UM  > Faculty of Health Sciences
Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy
Yuan Liu1; Christina S. Gong1; Lisen Lin1; Zijian Zhou1; Yijing Liu1; Zhen Yang1; Zheyu Shen1; Guocan Yu1; Zhantong Wang1; Sheng Wang1; Ying Ma1; Wenpei Fan1; Liangcan He1; Gang Niu1; Yunlu Dai2; Xiaoyuan Chen1
2019-04-13
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume9Issue:10Pages:2791-2799
Abstract

The design of hybrid metal-organic framework (MOF) nanomaterials by integrating inorganic nanoparticle into MOF (NP@MOF) has demonstrated outstanding potential for obtaining enhanced, collective, and extended novel physiochemical properties. However, the reverse structure of MOF-integrated inorganic nanoparticle (MOF@NP) with multifunction has rarely been reported.

Methods: We developed a facile in-situ growth method to integrate MOF nanoparticle into inorganic nanomaterial and designed a fluorescence switch to trigger enhanced photodynamic therapy. The influence of “switch” on the photodynamic activity was studied in vitro. The in vivo mice with tumor model was applied to evaluate the “switch”-triggered enhanced photodynamic therapy efficacy.

Results: A core-satellites structure with fluorescence off and on function was obtained when growing MnO2 on the surface of fluorescent zeolitic imidazolate framework (ZIF-8) nanoparticles. Furthermore, A core-shell structure with photodynamic activity off and on function was achieved by growing MnO2 on the surface of porphyrinic ZrMOF nanoparticles (ZrMOF@MnO2). Both the fluorescence and photodynamic activities can be turned off by MnO2 and turned on by GSH. The GSH-responsive activation of photodynamic activity of ZrMOF@MnO2 significantly depleted the intracellular GSH via a MnO2 reduction reaction, thus triggering an enhanced photodynamic therapy efficacy. Finally, the GSH-reduced Mn2+ provided a platform for magnetic resonance imaging-guided tumor therapy.

Conclusion: This work highlights the impact of inorganic nanomaterial on the MOF properties and provides insight to the rational design of multifunctional MOF-inorganic nanomaterial complexes.

KeywordMetal-organic Frameworks Core-shell Structure Fluorescence Switch Photodynamic Therapy
DOI10.7150/thno.34740
Indexed BySCIE
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000467276900005
PublisherIVYSPRING INT PUBL, PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
Fulltext Access
Citation statistics
Cited Times [WOS]:23   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorYunlu Dai; Xiaoyuan Chen
Affiliation1.Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, United States
2.Faculty of Health Sciences, University of Macau, Macau, SAR 999078, P. R. China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Yuan Liu,Christina S. Gong,Lisen Lin,et al. Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy[J]. THERANOSTICS,2019,9(10):2791-2799.
APA Yuan Liu,Christina S. Gong,Lisen Lin,Zijian Zhou,Yijing Liu,Zhen Yang,Zheyu Shen,Guocan Yu,Zhantong Wang,Sheng Wang,Ying Ma,Wenpei Fan,Liangcan He,Gang Niu,Yunlu Dai,&Xiaoyuan Chen.(2019).Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy.THERANOSTICS,9(10),2791-2799.
MLA Yuan Liu,et al."Core-shell metal-organic frameworks with fluorescence switch to trigger an enhanced photodynamic therapy".THERANOSTICS 9.10(2019):2791-2799.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Yuan Liu]'s Articles
[Christina S. Gong]'s Articles
[Lisen Lin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yuan Liu]'s Articles
[Christina S. Gong]'s Articles
[Lisen Lin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yuan Liu]'s Articles
[Christina S. Gong]'s Articles
[Lisen Lin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.