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Genome editing in fishes and their applications
Zhu, Bo; Ge, Wei

There have been revolutionary progresses in genome engineering in the past few years. The newly emerged genome editing technologies including zinc-finger nuclease (ZFN), transcription activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeats associated with Cas9 (CRISPR/Cas9) have enabled biological scientists to perform efficient and precise targeted genome editing in different species. Fish represent the largest group of vertebrates with many species having values for both scientific research and aquaculture industry. Genome editing technologies have found extensive applications in different fish species for basic functional studies as well as applied research in such fields as disease modeling and aquaculture. This mini-review focuses on recent advancements and applications of the new generation of genome editing technologies in fish species, with particular emphasis on their applications in understanding reproductive functions because the reproductive axis has been most systematically and best studied among others and its function has been difficult to address with reverse genetics approach.

KeywordGenome Editing Zfn Talen Crispr/cas9 Fish Teleosts
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Indexed BySCIE ; CPCI
WOS Research AreaEndocrinology & Metabolism
WOS SubjectEndocrinology & Metabolism
WOS IDWOS:000424858400002
The Source to ArticleWOS
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Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorGe, Wei
AffiliationCentre of Reproduction, Development and Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China
First Author AffilicationCentre of Reproduction, Development and Aging
Corresponding Author AffilicationCentre of Reproduction, Development and Aging
Recommended Citation
GB/T 7714
Zhu, Bo,Ge, Wei. Genome editing in fishes and their applications[J]. GENERAL AND COMPARATIVE ENDOCRINOLOGY,2018,257:3-12.
APA Zhu, Bo,&Ge, Wei.(2018).Genome editing in fishes and their applications.GENERAL AND COMPARATIVE ENDOCRINOLOGY,257,3-12.
MLA Zhu, Bo,et al."Genome editing in fishes and their applications".GENERAL AND COMPARATIVE ENDOCRINOLOGY 257(2018):3-12.
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