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Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy
Jingjing Wang1,2; Wei Sang3,4; Zhen Yang2; Zheyu Shen2; Zhantong Wang2; Orit Jacobson2; Yundai Chen1; Yong Wang5; Mingyan Shao5; Gang Niu,2; Yunlu Dai3,4; Xiaoyuan Chen2
2019-10-07
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Abstract

Combination therapy with multiple chemotherapeutic agents is the main approach for cancer treatment in the clinic. Polyphenol-based materials are found in our diet, demonstrate good biocompatibility, and prevent numerous diseases. In this study, we encapsulate two drugs in a single polyphenol-based polymer with Fe3+ or Mn2+ ions as the cross-linker for cancer therapy. The combination index of two drugs is an essential parameter to evaluate drug combinations. The amphiphilic polymer poly(ethylene glycol)-blockpolydopamine (PEG–PDA) was prepared by RAFT polymerization. The nanoparticles were prepared via self-assembly with Fe3+ or Mn2+ ions. Both doxorubicin (DOX) and simvastatin (SV) were encapsulated in the core of the nanoparticles. The cell viability and combination index were evaluated in vitro. The tumor accumulation of the nanoparticles was investigated by positron-emission tomography (PET) and magnetic resonance (MR) imaging. The as-prepared nanoparticles exhibited high drug loading capacity. The drug loaded nanoparticles could kill cancer cells effectively with a combination index <1. Both PET and MRI revealed that the nanoparticles showed long blood circulation time and high tumor accumulation. The nanoparticles could inhibit tumor inhibition via intravenous injection of nanoparticles. The polyphenolbased nanoplatform may serve as a promising theranostic candidate for clinical application.

DOI10.1039/c9tb01597c
Indexed BySCIE
Language英語English
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
CSCD IDWOS:000487804700009
PublisherROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
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Cited Times [WOS]:6   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorYunlu Dai; Xiaoyuan Chen
Affiliation1.Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China
2.Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA. E-mail: shawn.chen@nih.gov
3.Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China. E-mail: yldai@um.edu.mo
4.Cancer Centre, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China. E-mail: yldai@um.edu.mo
5.School of Life Science, Beijing University of Chinese Medicine, Beijing 100029, China
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Jingjing Wang,Wei Sang,Zhen Yang,et al. Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019.
APA Jingjing Wang,Wei Sang,Zhen Yang,Zheyu Shen,Zhantong Wang,Orit Jacobson,Yundai Chen,Yong Wang,Mingyan Shao,Gang Niu,,Yunlu Dai,&Xiaoyuan Chen.(2019).Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy.JOURNAL OF MATERIALS CHEMISTRY B.
MLA Jingjing Wang,et al."Polyphenol-based nanoplatform for MRI/PET dual-modality imaging guided effective combination chemotherapy".JOURNAL OF MATERIALS CHEMISTRY B (2019).
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