Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
Maram Hussein Zahra1; Tarek A.R. Salem2,3; Bishoy El-Aarag1,4; Nermeen Yosri5; Samah EL-Ghlban4; Kholoud Zaki5; Amel H. Marei5; Aida Abd El-Wahed5,6,7; Aamer Saeed8; Alfi Khatib9; Mohamed F. AlAjmi10; Abdulrahman M. Shathili11; Jianbo Xiao12; Shaden A. M. Khalifa13,14; Hesham R. El-Seedi5,6,11,15
Source PublicationMOLECULES


Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers.


The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model.


A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, 1H-NMR and 13C-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 µg/mL, respectively.


Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.

Keyword5,6-dehydrokawain Alpinia Zerumbet Ehrlich Ascites Carcinoma Anti-oxidant Anti-tumor
Indexed BySCIE
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000476700300149
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology,Okayama University, Okayama 7008530, Japan
2.Department of Biochemistry, College of Medicine, Qassim University, Al-Qassim 51452, Saudi Arabia
3.Department of Molecular Biology, Genetic Engineering & Biotechnology Institute, University of Sadat City,Sadat City 32958, Egypt
4.Biochemistry Division, Chemistry Department, Faculty of Science, Menoufia University,Shebin El-Koom 32512, Egypt
5.Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koom 32512, Egypt
6.Division of Pharmacognosy, Department of Medicinal Chemistry, Uppsala University, Biomedical Centre,Box 574, SE-751 23 Uppsala, Sweden
7.Department of Bee Research, Plant Protection Research Institute, Agricultural Research Centre,Giza 12627, Egypt
8.Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
9.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International Islamic University Malaysia,Kuantan 25200, Pahang, Malaysia
10.Pharmacognosy Group, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
11.Al-Rayan Research and Innovation Center, Al-Rayan Colleges, Medina 42541, Saudi Arabia
12.Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China
13.Clinical Research Centre, Karolinska University Hospital, 14186 Huddinge, Sweden
14.Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University,SE 106 91 Stockholm, Sweden
15.College of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
Recommended Citation
GB/T 7714
Maram Hussein Zahra,Tarek A.R. Salem,Bishoy El-Aarag,et al. Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities[J]. MOLECULES,2019,24(13).
APA Maram Hussein Zahra,Tarek A.R. Salem,Bishoy El-Aarag,Nermeen Yosri,Samah EL-Ghlban,Kholoud Zaki,Amel H. Marei,Aida Abd El-Wahed,Aamer Saeed,Alfi Khatib,Mohamed F. AlAjmi,Abdulrahman M. Shathili,Jianbo Xiao,Shaden A. M. Khalifa,&Hesham R. El-Seedi.(2019).Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities.MOLECULES,24(13).
MLA Maram Hussein Zahra,et al."Alpinia zerumbet(Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities".MOLECULES 24.13(2019).
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