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Antihyperglycemic and antihyperlipidemic activities of a polysaccharide from Physalis pubescensL. in streptozotocin (STZ)-induceddiabetic mice
Xiaoyong Chen1,2; Xiong Li1,2; Xiaobo Zhang1,2; Lijun You1,2; Peter Chi-Keung Cheung3; Riming Huang4; Jianbo Xiao5
2019-08
Source PublicationFOOD & FUNCTION
ISSN2042-6496
Volume10Issue:8Pages:4868-4876
Abstract

In this study, a polysaccharide was extracted from Physalis pubescens L. (named PP). Its antihyperglycemic and antihyperlipidemic activities were evaluated in STZ-induced diabetic mice. Results showed that PP was determined to be composed of rhamnose (Rha), arabinose (Ara), fucose (Fuc), xylose (Xyl), mannose (Man), glucose (Glc) and galactose (Gal) with molar percentages of 4.65%, 17.34%, 1.43%, 6.24%, 5.52%, 45.5%, and 19.31%, respectively. The average molecular weight (Mw) was found to be 20.0 kDa. It had a strong α-glucosidase inhibitory activity in vitro. PP treatment could enhance the oral glucose tolerance, and increase the levels of SOD, GSH, CAT, vitamin C, vitamin E, HDL-c, C-peptide, GCK and hepatic glycogen in diabetic mice. Besides, PP treatment could also decrease the levels of MDA, TG, TC, LDL-c, BUN and G-6-Pase. The regulating effects were stronger in high dose PP treatment than those in the low and medium dose treatments. In short, PP played an important role in protecting STZ-induced diabetic mice, and the effect was closely related to its activities in antioxidation and regulating glucose and lipid metabolism.

DOI10.1039/c9fo00687g
WOS Research AreaBiochemistry & Molecular Biology ; Food Science & Technology
WOS SubjectBiochemistry & Molecular Biology ; Food Science & Technology
WOS IDWOS:000481481700033
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.School of Food Science and Engineering, South China University of Technology,Guangzhou, Guangdong, 510640, People’s Republic of China
2.Overseas Expertise Introduction Center for Food Nutrition and Human Health(111 Center), Guangzhou, 510640, People’s Republic of China
3.Food and Nutritional Sciences, School of Life Sciences, The Chinese University ofHong Kong, Shatin, Hong Kong SAR
4.Guangdong Provincial Key Laboratory of Food Quality and Safety, College of FoodScience, South China Agricultural University, Guangzhou 510642, China
5.Institute of Chinese Medical Sciences, University of Macau, Avenida da universidade,Taipa, Macau
Recommended Citation
GB/T 7714
Xiaoyong Chen,Xiong Li,Xiaobo Zhang,et al. Antihyperglycemic and antihyperlipidemic activities of a polysaccharide from Physalis pubescensL. in streptozotocin (STZ)-induceddiabetic mice[J]. FOOD & FUNCTION,2019,10(8):4868-4876.
APA Xiaoyong Chen,Xiong Li,Xiaobo Zhang,Lijun You,Peter Chi-Keung Cheung,Riming Huang,&Jianbo Xiao.(2019).Antihyperglycemic and antihyperlipidemic activities of a polysaccharide from Physalis pubescensL. in streptozotocin (STZ)-induceddiabetic mice.FOOD & FUNCTION,10(8),4868-4876.
MLA Xiaoyong Chen,et al."Antihyperglycemic and antihyperlipidemic activities of a polysaccharide from Physalis pubescensL. in streptozotocin (STZ)-induceddiabetic mice".FOOD & FUNCTION 10.8(2019):4868-4876.
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