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Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice
Li, Ao1,2; Zhang, Jing-Yao2; Xiao, Xiao2; Wang, Song-Song1; Wan, Jian-Bo1; Chai, Yu-Shuang3; Li, Peng1; Wang, Yi-Tao1
2018-09
Source PublicationFOOD AND CHEMICAL TOXICOLOGY
ISSN0278-6915
Volume119Pages:445-456
Abstract

An-Gong-Niu-Huang Wan (AGNH) is a famous traditional Chinese medicine prescription that contains cinnabar (HgS) and realgar (As2S2); the clinical practice of AGNH is hindered because both mercury and arsenic are hepatorenal toxic metalloids. It is noted that the cinnabar and realgar in AGNH are not used alone, but rather combined with different kinds of medicinal herbs as a formula to use. In this study, we evaluated the hepatorenal protective effects of the medicinal herbs in AGNH after co-exposure to cinnabar and realgar for 4 weeks in mice. The combination of the herbs in AGNH alleviated cinnabar and realgar-induced histopathological alterations and oxidative stress in the liver and kidneys. Furthermore, in cinnabar and realgar-treated mice, the increased expression levels of inducible enzymes (COX-2 and iNOS) and proinflammatory mediators (IL-1 beta, TNF-alpha, PGE2 and NO) in the liver and kidneys were consistently down-regulated when medicinal herbs were combined as a formula. We also found that the herbs could reduce the inflammatory response by the inactivation of the MAPK and PI3K/Akt signaling pathway and the resulting blockade of NF-kappa B activation. Overall, our data indicates that the herbal medicines in AGNH attenuate cinnabar and realgar-induced hepatorenal toxicity by improving antioxidant competence and suppressing inflammatory injury.

KeywordAn-gong-niu-huang Wan Cinnabar Realgar Oxidative Stress Inflammation Detoxification
DOI10.1016/j.fct.2017.11.054
URLView the original
Indexed BySCIE ; CPCI-S
Language英語English
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000443664200054
PublisherPERGAMON-ELSEVIER SCIENCE LTD
The Source to ArticleWOS
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChai, Yu-Shuang; Li, Peng; Wang, Yi-Tao
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China
2.College of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China
3.Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd, Guangzhou, 510530, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Li, Ao,Zhang, Jing-Yao,Xiao, Xiao,et al. Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice[J]. FOOD AND CHEMICAL TOXICOLOGY,2018,119:445-456.
APA Li, Ao,Zhang, Jing-Yao,Xiao, Xiao,Wang, Song-Song,Wan, Jian-Bo,Chai, Yu-Shuang,Li, Peng,&Wang, Yi-Tao.(2018).Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice.FOOD AND CHEMICAL TOXICOLOGY,119,445-456.
MLA Li, Ao,et al."Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice".FOOD AND CHEMICAL TOXICOLOGY 119(2018):445-456.
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