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Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines
Tongkai Chen1; Bing He2,4; Jingsong Tao3; Yuan He3; Hailiang Deng2; Xueqing Wang2; Ying Zheng3
2019-03-15
Source PublicationAdvanced Drug Delivery Reviews
ISSN0169-409X
Volume143Pages:177-205
Abstract

Extensive studies on nanomedicines have been conducted for drug delivery and disease diagnosis (especially for cancer therapy). However, the intracellular and in vivo biofate of nanomedicines, which is significantly associated with their clinical therapeutic effect, is poorly understood at present. This is because of the technical challenges to quantify the disassembly and behaviour of nanomedicines. As a fluorescence- and distance-based approach, the Förster Resonance Energy Transfer (FRET) technique is very successful to study the interaction of nanomedicines with biological systems. In this review, principles on how to select a FRET pair and construct FRET-based nanomedicines have been described first, followed by their application to study structural integrity, biodistribution, disassembly kinetics, and elimination of nanomedicines at intracellular and in vivo levels, especially with drug nanocarriers including polymeric micelles, polymeric nanoparticles, and lipid-based nanoparticles. FRET is a powerful tool to reveal changes and interaction of nanoparticles after delivery, which will be very useful to guide future developments of nanomedicine.

KeywordFörster Resonance Energy Transfer (Fret) Nanomedicines Integrity Biofate Micelles Polymeric Nanoparticles Lipid-based Nanoparticles
DOIhttps://doi.org/10.1016/j.addr.2019.04.009
Indexed BySCIE
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000488318000010
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Cited Times [WOS]:32   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorXueqing Wang; Ying Zheng
Affiliation1.Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
2.Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery System, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
4.State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Tongkai Chen,Bing He,Jingsong Tao,et al. Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines[J]. Advanced Drug Delivery Reviews,2019,143:177-205.
APA Tongkai Chen,Bing He,Jingsong Tao,Yuan He,Hailiang Deng,Xueqing Wang,&Ying Zheng.(2019).Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines.Advanced Drug Delivery Reviews,143,177-205.
MLA Tongkai Chen,et al."Application of Forster Resonance Energy Transfer (FRET) technique to elucidate intracellular and In Vivo biofate of nanomedicines".Advanced Drug Delivery Reviews 143(2019):177-205.
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