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Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment
Xu Wu1; Wei Hu2; Lan Lu3; Yueshui Zhao1; Yejiang Zhou4; Zhangang Xiao1; Lin Zhang1,5; Hanyu Zhang1; Xiaobing Li1; Wanping Li1; Shengpeng Wang6; Chi Hin Cho1; Jing Shen1; Mingxing Li1

Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components. Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, we summarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent.

KeywordVitamin d 1α,25-dihydroxyvitamin D3 Tumor Microenvironment Cancer Stem Cell Tumor-infiltrating Lymphocyte Tumor-derived Endothelial Cell Cancer-associated Fibroblast
Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000461052500001
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Cited Times [WOS]:37   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou646000, China
2.Department of Gastroenterology, Shenzhen Hospital, Southern Medical University, Shenzhen 518000, China
3.Sichuan Industrial Institute of Antibiotics, Chengdu University, Chengdu 610106, China
4.Department of Gastrointestinal Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
5.Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China
6.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao,China
Recommended Citation
GB/T 7714
Xu Wu,Wei Hu,Lan Lu,et al. Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment[J]. ACTA PHARMACEUTICA SINICA B,2019,9(2):203-219.
APA Xu Wu,Wei Hu,Lan Lu,Yueshui Zhao,Yejiang Zhou,Zhangang Xiao,Lin Zhang,Hanyu Zhang,Xiaobing Li,Wanping Li,Shengpeng Wang,Chi Hin Cho,Jing Shen,&Mingxing Li.(2019).Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment.ACTA PHARMACEUTICA SINICA B,9(2),203-219.
MLA Xu Wu,et al."Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment".ACTA PHARMACEUTICA SINICA B 9.2(2019):203-219.
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