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Function of Nogo-A/Nogo-A Receptor in Alzheimer's Disease
Xu YQ1; Sun ZQ2; Wang YT1; Xiao F1,2; Chen MW1
AbstractNogo-A is a protein inhibiting axonal regeneration, which is considered a major obstacle to nerve regeneration after injury in mammals. Rapid progress has been achieved in new physiopathological function of Nogo-A in Alzheimer's disease in the past decade. Recent research shows that through binding to Nogo-A receptor, Nogo-A plays an important role in Alzheimer's disease (AD) pathogenesis. Particularly, Nogo-A/Nogo-A receptors modulate the generation of amyloid β-protein (Aβ), which is thought to be a major cause of AD. This review describes the recent development of Nogo-A, Nogo-A receptor, and downstream signaling involved in AD and pharmacological basis of therapeutic drugs. We concluded the Nogo-A/Nogo-A receptor provide new insight into potential mechanisms and promising therapy strategies in AD.
KeywordAlzheimer's Disease Nogo-a Receptor Nogo-a
Indexed BySCI
WOS Research AreaNeurosciences & Neurology ; Pharmacology & Pharmacy
WOS SubjectNeurosciences ; Pharmacology & Pharmacy
WOS IDWOS:000354646500001
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Cited Times [WOS]:10   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
2.Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, China.
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Xu YQ,Sun ZQ,Wang YT,et al. Function of Nogo-A/Nogo-A Receptor in Alzheimer's Disease[J]. CNS NEUROSCIENCE & THERAPEUTICS,2015,21(6):479-485.
APA Xu YQ,Sun ZQ,Wang YT,Xiao F,&Chen MW.(2015).Function of Nogo-A/Nogo-A Receptor in Alzheimer's Disease.CNS NEUROSCIENCE & THERAPEUTICS,21(6),479-485.
MLA Xu YQ,et al."Function of Nogo-A/Nogo-A Receptor in Alzheimer's Disease".CNS NEUROSCIENCE & THERAPEUTICS 21.6(2015):479-485.
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