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Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells
Tingyan Hu1; Kegang Linghu1; Siqi Huang2; Maurizio Battino3; Milen I. Georgiev4; Gokhan Zengin5; Defang Li2; Yun Deng6; Y.T. Wang1; Hui Cao6,7
Source PublicationFood and Chemical Toxicology

Significant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. The MCF-7 cells treated with flaxseed extract showed a dose-dependent decrease in cell viability. The flaxseed extract induced reactive oxygen species and the flow cytometric analysis demonstrated that flaxseed fatty acids triggered apoptosis of MCF-7 cells, which was also shown by the loss of mitochondrial membrane potential and caspase cascade reaction. Thus, the flaxseed extract regulated the growth of MCF-7 cells and induced apoptosis. Eventually, the flaxseed could be used as a dietary supplement to prevent breast cancer.

KeywordFlaxseed Mcf-7 cells Apoptosis Ros Mitochondrial Membrane Potential Dietary Supplement
Indexed BySCIE ; CPCI-S
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000467512200022
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorSiqi Huang; Hui Cao
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine, University of Macau, Macau, China
2.Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, Changsha, Hunan, China
3.Department of Clinical Sciences, Faculty of Medicine, Università Politecnica Delle Marche, Ancona, Ancona, Italy
4.Laboratory of Applied Biotechnologies, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv, Bulgaria
5.Department of Biology, Science Faculty, Selcuk University, Konya, Turkey
6.School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China
7.Guangdong-Macau Traditional Chinese Medicine Technology Industrial Park Development Co., Ltd, Hengqin New Area, Zhuhai, Guangdong, 519031, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Tingyan Hu,Kegang Linghu,Siqi Huang,et al. Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells[J]. Food and Chemical Toxicology,2019,127:188-196.
APA Tingyan Hu,Kegang Linghu,Siqi Huang,Maurizio Battino,Milen I. Georgiev,Gokhan Zengin,Defang Li,Yun Deng,Y.T. Wang,&Hui Cao.(2019).Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells.Food and Chemical Toxicology,127,188-196.
MLA Tingyan Hu,et al."Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells".Food and Chemical Toxicology 127(2019):188-196.
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