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Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis
Leung, CH1; Wu, KJ1; Li, GD1; Wu, C2; Ko, CG2; Ma, DL2
2019
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume117Pages:78-83
AbstractCirculating tumor cells (CTCs) are an important biomarker for various types of cancers. As CTCs are extremely rare in the bloodstream, the accurate analysis and efficient separation of CTCs is a challenging task. In order to develop new diagnostic approaches for cancer research, understanding the functional characteristics of biomolecules at the single-molecule level in individual cancer cells is required. Meanwhile, microfluidic platforms have emerged as a promising technology for analyzing single molecules and single cells. In this review, we discuss some label-free techniques for biomolecule detection and highlight some reports that have employed combined label-free techniques with microfluidics for individual molecule or cancer cell analysis. Finally, we offer our perspective of the integration of label-free techniques with microfluidic technology on future applications.
KeywordNucleic-acid Analysis Microfluidics Label-free Circulating Tumor Cells Protein Analysis
DOI10.1016/j.trac.2019.06.003
Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
WOS IDWOS:000482209800009
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa, DL
Affiliation1.University of MacauInst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Zhuhai, Macao, Peoples R China
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Leung, CH,Wu, KJ,Li, GD,et al. Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2019,117:78-83.
APA Leung, CH,Wu, KJ,Li, GD,Wu, C,Ko, CG,&Ma, DL.(2019).Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,117,78-83.
MLA Leung, CH,et al."Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 117(2019):78-83.
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