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A Comparative Study on Immunomodulatory Activity of Polysaccharides from Two Official Species of Ganoderma (Lingzhi)
Lan-Zhen Meng1; Jing Xie1; Guang-Ping Lv1; De-Jun Hu1; Jing Zhao1; Jin-Ao Duan2; Shao-Ping Li1
2014-10
Source PublicationNUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
ISSN0163-5581
Volume66Issue:7Pages:1124-1131
Abstract

Two Ganoderma species, G. lucidum and G. sinense, are listed as Lingzhi in Chinese Pharmacopoeia and they are considered to have the same therapeutic effects. Polysaccharides were the main immunomodulatory and anticancer components in Ganoderma. In this study, the chemical characters and the effects of polysaccharides from G. lucidum (GLPS) and G. sinense (GSPS) on macrophage functions were investigated and compared. Chemical studies showed that GLPS and GSPS were different, displaying various molecular weight distribution and ratio of monosaccharide components. In vitro pharmacological studies showed that both GLPS and GSPS had potent effects on macrophage functions, such as promoting macrophage phagocytosis, increasing their release of nitric oxide and cytokines interleukin (IL)-1 alpha, IL-6, IL-10, and tumor necrosis factor-alpha. Generally, GLPS was more powerful than GSPS. This study is helpful to elucidate the active components and pharmacological variation between the 2 Ganoderma species. The structure-activity relationship of polysaccharides from Ganoderma needs further study.

DOI10.1080/01635581.2014.948215
Indexed BySCIE
Language英語English
WOS Research AreaOncology ; Nutrition & Dietetics
WOS SubjectOncology ; Nutrition & Dietetics
WOS IDWOS:000343236100005
PublisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
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Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorJing Zhao
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
2.Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Lan-Zhen Meng,Jing Xie,Guang-Ping Lv,et al. A Comparative Study on Immunomodulatory Activity of Polysaccharides from Two Official Species of Ganoderma (Lingzhi)[J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,2014,66(7):1124-1131.
APA Lan-Zhen Meng,Jing Xie,Guang-Ping Lv,De-Jun Hu,Jing Zhao,Jin-Ao Duan,&Shao-Ping Li.(2014).A Comparative Study on Immunomodulatory Activity of Polysaccharides from Two Official Species of Ganoderma (Lingzhi).NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL,66(7),1124-1131.
MLA Lan-Zhen Meng,et al."A Comparative Study on Immunomodulatory Activity of Polysaccharides from Two Official Species of Ganoderma (Lingzhi)".NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 66.7(2014):1124-1131.
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