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Interpolated average CT for PET attenuation correction in different lesion characteristics
Cobie Y.T. Ho1; Tung-Hsin Wu2; Greta S.P. Mok1
2016-03
Source PublicationNUCLEAR MEDICINE COMMUNICATIONS
ISSN0143-3636
Volume37Issue:3Pages:297-306
Abstract

Objective Previously we proposed using an interpolated average computed tomography (IACT) method as a lowdose alternate of cine average computed tomography (CACT) for PET attenuation correction (AC). This study aims to evaluate its performance for thoracic lesions with different characteristics in simulations and clinical patients. Materials and methods We used the XCAT phantom to simulate noisy fluorine-18 fluorodeoxyglucose (18F-FDG) distribution with respiratory motion amplitudes of 2 and 3 cm. Average activity and attenuation maps represented static PET and CACT, respectively. IACT was generated by the end-inspiration and end-expiration phases of the attenuation maps (HCT-in and HCT-ex) using a deformable registration method. Spherical lesions with diameters of 10 and 20 mm with four target-to-background ratios (TBRs) were simulated at four different locations individually, including the lower left lung, lower right lung, middle right lung, and upper right lung. Five patients with a total of six thoracic lesions were recruited. They were scanned 1 h after 315–480 MBq 18F-FDG injection. Simulated and clinical PET sinograms were reconstructed with AC using (i) CACT, (ii) IACT, and (iii) helical computed tomography (HCTs). The TBRs and mean standardized uptake value were analyzed. Results Significant artifacts were observed in PETHCTs from visual assessment. For both simulation and clinical study, PETIACT was more similar to PETCACT in terms of TBRs and mean standardized uptake value. The differences between CACT/IACT and HCTs were more significant for lesions located at the lower lungs. Conclusion The IACT is a robust and low-dose AC method for improved thoracic lesion localization and quantitation for a wide range of lesion characteristics. Nucl Med Commun 37:297–306 Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

KeywordAttenuation Correction Thoracic Lesions Pet/ct Respiratory Artifacts Simulations
DOIhttp://doi.org/10.1097/MNM.0000000000000435
Indexed BySCI
Language英语
WOS Research AreaRadiology ; Nuclear Medicine & Medical Imaging
WOS SubjectRadiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000373526600012
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Science and Technology
DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Corresponding AuthorGreta S.P. Mok
Affiliation1.Biomedical Imaging Laboratory, Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Macau, China
2.Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
First Author AffilicationFaculty of Science and Technology
Corresponding Author AffilicationFaculty of Science and Technology
Recommended Citation
GB/T 7714
Cobie Y.T. Ho,Tung-Hsin Wu,Greta S.P. Mok. Interpolated average CT for PET attenuation correction in different lesion characteristics[J]. NUCLEAR MEDICINE COMMUNICATIONS,2016,37(3):297-306.
APA Cobie Y.T. Ho,Tung-Hsin Wu,&Greta S.P. Mok.(2016).Interpolated average CT for PET attenuation correction in different lesion characteristics.NUCLEAR MEDICINE COMMUNICATIONS,37(3),297-306.
MLA Cobie Y.T. Ho,et al."Interpolated average CT for PET attenuation correction in different lesion characteristics".NUCLEAR MEDICINE COMMUNICATIONS 37.3(2016):297-306.
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