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Effect on platelet aggregation activity: extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis
Chen Cen1; Wang Fengqin1; Xiao Wen1; Xia Zhining1; Hu Guang2; Wan Jianbo3; Yang Fengqing1
2017-02-15
Source PublicationJOURNAL OF TRADITIONAL CHINESE MEDICINE
ISSN0255-2922
Volume37Issue:1Pages:64-75
Abstract

OBJECTIVE: To evaluate the anti-platelet aggregation effects of extracts from 31 Traditional Chinese Medicines (TCM) with the property of activating blood and resolving stasis in terms of TCM theory.

METHODS:The 31 TCMs extracts were prepared using water, 90% ethanol and ethyl acetate., and the effects on.anti-platelet aggregation were tested on a platelet aggregation analyzer in vitro with adenosine 5'-diphosphate; bovine thrombin and arachi- donic acid (AA) as aggregation inducers, respectively. Aspirin was the positive control.

RESULTS: Lots of the tested TCMs had inhibitory effects with concentration-dependent manner on platelet aggregations induced by various agonists. Especially, some of the TCMs such as Chuanxiong (Rhizoma Chuanxiong), Yanhusuo (Rhizoma Corydalis Yanhusuo) and Danshen (Radix Salviae Miltiorrhizae) showed good anti-platelet aggregation effect similar or higher than thatin positive control group.

CONCLUSION: The study provided scientific references that several TCMs such as Chuanxiong (Rhizoma Chuanxiong), Yanhusuo (Rhizoma Corydalis Yanhusuo) and Danshen (Radix Salviae Miltiorrhizae), possess the property of anti-platelet aggregation.

KeywordPlatelet Aggregation Inhibitors Adenosine Diphosphate Thrombin Arachidonic Acid Blood Activating Stasis Removing Medicine Chinese Traditional
URLView the original
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000392907100009
PublisherJOURNAL TRADITIONAL CHINESE MED
The Source to ArticleWOS
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Cited Times [WOS]:12   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYang Fengqing
Affiliation1.Chongqing Univ, Sch Chem & Chem Engn, Chongqing 400030, Peoples R China
2.Chongqing Univ Technol, Sch Pharm & Bioengn, Chongqing 400054, Peoples R China
3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Recommended Citation
GB/T 7714
Chen Cen,Wang Fengqin,Xiao Wen,et al. Effect on platelet aggregation activity: extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2017,37(1):64-75.
APA Chen Cen.,Wang Fengqin.,Xiao Wen.,Xia Zhining.,Hu Guang.,...&Yang Fengqing.(2017).Effect on platelet aggregation activity: extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis.JOURNAL OF TRADITIONAL CHINESE MEDICINE,37(1),64-75.
MLA Chen Cen,et al."Effect on platelet aggregation activity: extracts from 31 Traditional Chinese Medicines with the property of activating blood and resolving stasis".JOURNAL OF TRADITIONAL CHINESE MEDICINE 37.1(2017):64-75.
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