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New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect
Feng, Zhe-Ling1,2; Zhang, Tian1; Liu, Jing-Xin1; Chen, Xiu-Ping1; Gan, Li-She3; Ye, Yang2; Lin, Li-Gen1,2

Podolactones are a class of structural diverse diterpenoid lactones, mainly isolated from the Podocarpus species. Several bioactivities have been disclosed for podolactones, including cytotoxicity and anti-atherosclerosis. In this study, the seeds of P. nagi were isolated by comprehensive chromatographic methods to obtain three new podolatones, named nagilactone B 1-O-beta-d-glucoside (1), nagilactone N3 3-O-beta-d-glucoside (2), and 2-epinagilactone B (3), as well as a known compound, nagilactone B (4). Their structures were determined by analyses of NMR and HRESIMS data. Compounds 1 and 2 significantly inhibited nitric oxide (NO) production on LPS-stimulated RAW264.7 macrophages, with IC50 values of 0.18 +/- 0.04 and 0.53 +/- 0.03 mu M, respectively. Indomethacin (IC50 4.21 +/- 0.32 mu M) was used as a positive control. Compound 1 suppressed the expression of inducible NO synthase (iNOS) in a concentration-dependent manner, mediating through inhibiting nuclear factor-kappa B (NF-kappa B) activity. This is the first report regarding the anti-inflammatory effect of podolactones, which could be potential anti-inflammatory agents.

KeywordPodocarpus Nagi Podolactones Anti-inflammation No Production Nf-kappa b
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Indexed BySCIE
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000441557000007
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau 999078, China
2.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu-Chong-Zhi Road, Zhangjiang Hi-tech Park, Shanghai 201203, China
3.College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Feng, Zhe-Ling,Zhang, Tian,Liu, Jing-Xin,et al. New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect[J]. JOURNAL OF NATURAL MEDICINES,2018,72(4):882-889.
APA Feng, Zhe-Ling,Zhang, Tian,Liu, Jing-Xin,Chen, Xiu-Ping,Gan, Li-She,Ye, Yang,&Lin, Li-Gen.(2018).New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect.JOURNAL OF NATURAL MEDICINES,72(4),882-889.
MLA Feng, Zhe-Ling,et al."New podolactones from the seeds of Podocarpus nagi and their anti-inflammatory effect".JOURNAL OF NATURAL MEDICINES 72.4(2018):882-889.
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