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Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients
Kuok, Kit Ieng1; Li, Shengke1; Wyman, Ian W.2; Wang, Ruibing1
2017-06
Source PublicationANNALS OF THE NEW YORK ACADEMY OF SCIENCES
ISSN0077-8923
Volume1398Issue:1Pages:108-119
Abstract

Cucurbit[7] uril (CB[7]), belonging to the cucurbit[n] uril family (CB[n], n = 5-8, 10, or 13-15), may form hostguest complexes with a variety of small molecules of biomedical interest. The physical and chemical properties of the complexed drugs are often improved as a result of this complexation, suggesting the potential application of CB[7] as a pharmaceutical excipient. This review has summarized the most recent research progress reported between 2011 and early 2017 regarding the biocompatibility of CB[7] and the influence of CB[7] on the stability, solubility, biouptake, and biological activities (including therapeutic efficacies and toxicities) of guest drug molecules. Through this systemic summary and analysis, we intend to stimulate further research efforts in this area and promote the use of CB[7] as an emerging pharmaceutical excipient to improve various properties of drug molecules (or active pharmaceutical ingredients).

KeywordCucurbit[7]Uril Host-guest Complexes Supramolecular Chemistry Excipients Formulation
DOIhttp://doi.org/10.1111/nyas.13376
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000405457600010
PublisherWILEY
The Source to ArticleWOS
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Cited Times [WOS]:68   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Ruibing
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau,Taipa, Macau SAR, China.
2.Department of Chemistry, Queen’s University, Kingston, Ontario, Canada
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Kuok, Kit Ieng,Li, Shengke,Wyman, Ian W.,et al. Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,2017,1398(1):108-119.
APA Kuok, Kit Ieng,Li, Shengke,Wyman, Ian W.,&Wang, Ruibing.(2017).Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients.ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,1398(1),108-119.
MLA Kuok, Kit Ieng,et al."Cucurbit[7]uril: an emerging candidate for pharmaceutical excipients".ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1398.1(2017):108-119.
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