Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases
Cao, Yiwei; Wang, Rui-Hong
Source PublicationAGING AND DISEASE
AbstractAccumulating epidemiological studies have implicated a strong link between age associated metabolic diseases and cancer, though direct and irrefutable evidence is missing. In this review, we discuss the connection between Warburg effects and tumorigenesis, as well as adaptive responses to environment such as circadian rhythms on molecular pathways involved in metabolism. We also review the central role of the sirtuin family of proteins in physiological modulation of cellular processes and age-associated metabolic diseases. We also provide a macroscopic view of how the circadian rhythm affects metabolism and may be involved in cell metabolism reprogramming and cancer pathogenesis. The aberrations in metabolism and the circadian system may lead to age-associated diseases directly or through intermediates. These intermediates may be either mutated or reprogrammed, thus becoming responsible for chromatin modification and oncogene transcription. Integration of circadian rhythm and metabolic reprogramming in the holistic understanding of metabolic diseases and cancer may provide additional insights into human diseases.
KeywordAge-associated diseases circadian rhythm metabolic reprogramming sirtuin tumorigenesis Warburg effect
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Indexed BySCI
WOS Research AreaGeriatrics & Gerontology
WOS SubjectGeriatrics & Gerontology
WOS IDWOS:000404530200007
The Source to ArticleWOS
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Cited Times [WOS]:15   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
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GB/T 7714
Cao, Yiwei,Wang, Rui-Hong. Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases[J]. AGING AND DISEASE,2017,8(3):314-333.
APA Cao, Yiwei,&Wang, Rui-Hong.(2017).Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases.AGING AND DISEASE,8(3),314-333.
MLA Cao, Yiwei,et al."Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases".AGING AND DISEASE 8.3(2017):314-333.
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