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Activated carbon as a carrier for amorphous drug delivery: Effect of drug characteristics and carrier wettability
Miriyala, Nikhila1; Ouyang, Defang2; Perrie, Yvonne3; Lowry, Deborah4; Kirby, Daniel J.1
2017-06
Source PublicationEUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
ISSN0939-6411
Volume115Pages:197-205
Abstract

Recent research on porous silica materials as drug carriers for amorphous and controlled drug delivery has shown promising results. However, due to contradictory literature reports on toxicity and high costs of production, it is important to explore alternative safe and inexpensive porous carriers. In this study, the potential of activated carbon (AC) as an amorphous drug carrier was investigated using paracetamol (PA) and ibuprofen (IBU) as model drugs. The solution impregnation method was used for drug loading, with loading efficiency determined by UV spectroscopy and drug release kinetics studied using USP II dissolution apparatus. The physical state of the drug in the complex was characterised using differential scanning calorimetry and X-ray diffractions techniques, whilst sites of drug adsorption were studied using Fourier transform infrared spectroscopy and N-2 adsorption techniques. In addition, the cytotoxicity of AC on human colon carcinoma (Caco-2) cells was assessed using the MIT assay. Results presented here reveal that, for PA/AC and IBU/AC complexes, the saturation solubility of the drug in the loading solvent appears to have an effect on the drug loading efficiency and the physical state of the drug loaded; whilst drug release kinetics were affected by the wettability of the activated carbon particles. Furthermore, activated carbon microparticles exhibited very low cytotoxicity on Caco-2 cells at the concentrations tested (10-800 mu g/mL). This study, therefore, supports the potential of activated carbon as a carrier for amorphous drug delivery. (C) 2017 Elsevier B.V. All rights reserved.

KeywordActivated Carbon Amorphous Drug Delivery Paracetamol Ibuprofen Oral Drug Delivery Porous Carrier
DOI10.1016/j.ejpb.2017.03.002
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000401686000020
PublisherELSEVIER SCIENCE BV
The Source to ArticleWOS
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Cited Times [WOS]:28   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorKirby, Daniel J.
Affiliation1.Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, China
3.Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, Scotland, United Kingdom
4.School of Pharmacy and Pharmaceutical Sciences, Ulster University, United Kingdom
Recommended Citation
GB/T 7714
Miriyala, Nikhila,Ouyang, Defang,Perrie, Yvonne,et al. Activated carbon as a carrier for amorphous drug delivery: Effect of drug characteristics and carrier wettability[J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,2017,115:197-205.
APA Miriyala, Nikhila,Ouyang, Defang,Perrie, Yvonne,Lowry, Deborah,&Kirby, Daniel J..(2017).Activated carbon as a carrier for amorphous drug delivery: Effect of drug characteristics and carrier wettability.EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS,115,197-205.
MLA Miriyala, Nikhila,et al."Activated carbon as a carrier for amorphous drug delivery: Effect of drug characteristics and carrier wettability".EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 115(2017):197-205.
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