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C-21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents
Huang, Lie-Jun1,3; Chen, Shao-Ru2; Yuan, Chun-Mao1; Gu, Wei1; Guo, Bao-Jian2; Wang, Yi-Tao2; Wang, Ying2; Hao, Xiao-Jiang1

During the screening of natural anti-inflammatory agent, we identified some C21-steroidal pregnane sapogenins or the derivatives to inhibit TLR2, TLR3, and TLR4-initiated inflammatory responses respectively. Treatment with active compounds 10, 2j and 3p failed to impact tumor necrosis factor-ot (TNF-a) induced nucleus translocation of NF-kappa B p65 subunit. However, these compounds regulated distinct canonical or non-canonical NF-kappa B family members. Ectopic expression of TNF receptor associated factor 6 (TRAF6) abrogated the inhibitory activity of the compounds on production of pro-inflammatory cytokines downstream of TLR4. These results suggested that compounds 10, 2j, and 3p suppressed TLRinitiated innate immunity through TRAF6 with differential regulation of NF-KB family proteins. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordC21-steroidal Pregnane Steroids Anti-inflammation Tlr Nf-kappa b Traf6
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Indexed BySCI ; IC
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
WOS IDWOS:000402941700022
The Source to ArticleWOS
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorWang, Ying; Hao, Xiao-Jiang
Affiliation1.State Key Laboratory of Functions and Applications of Medicinal Plants, Guiyang 550002, People’s Republic of China
2.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao SAR, China
3.Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, People’s Republic of China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang, Lie-Jun,Chen, Shao-Ru,Yuan, Chun-Mao,et al. C-21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2017,25(13):3512-3524.
APA Huang, Lie-Jun.,Chen, Shao-Ru.,Yuan, Chun-Mao.,Gu, Wei.,Guo, Bao-Jian.,...&Hao, Xiao-Jiang.(2017).C-21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents.BIOORGANIC & MEDICINAL CHEMISTRY,25(13),3512-3524.
MLA Huang, Lie-Jun,et al."C-21-steroidal pregnane sapogenins and their derivatives as anti-inflammatory agents".BIOORGANIC & MEDICINAL CHEMISTRY 25.13(2017):3512-3524.
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