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Meloslines A and B, two novel indole alkaloids from Alstonia scholaris
Kuok, Chiu-Fai1,2; Zhang, Jian2,3; Fan, Chun-Lin2; Zhang, Qing-Wen3; Fan, Run-Zhu2; Zhang, Dong-Mei2; Zhang, Xiao-Qi2; Ye, Wen-Cai1,2

An unprecedented indole alkaloid melosline A (1), with 6/5/6/6 tetracyclic ring skeleton, together with a new alkaloid melosline B (2) and one known compound (3) were isolated from the leaves and twigs of Alstonia scholaris. The new structures were elucidated by comprehensive spectroscopic analysis. The absolute configuration of compound 1 was confirmed by comparison of experimental data with calculated electronic circular dichroism (ECD). Compound 1 exhibited moderate cytotoxicity against MCF-7 cancer cell lines. (C) 2017 Elsevier Ltd. All rights reserved.

KeywordIndole Alkaloids Alstonia Scholaris Absolute Configuration Cytotoxicity
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Indexed BySCI ; IC
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000405048100014
The Source to ArticleWOS
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZhang, Xiao-Qi; Ye, Wen-Cai
Affiliation1.Department of Phytochemistry, China Pharmaceutical University, Nanjing 210009, People’s Republic of China
2.Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernazation of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, People’s Republic of China
3.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao SAR, People’s Republic of China
Recommended Citation
GB/T 7714
Kuok, Chiu-Fai,Zhang, Jian,Fan, Chun-Lin,et al. Meloslines A and B, two novel indole alkaloids from Alstonia scholaris[J]. TETRAHEDRON LETTERS,2017,58(28):2740-2742.
APA Kuok, Chiu-Fai.,Zhang, Jian.,Fan, Chun-Lin.,Zhang, Qing-Wen.,Fan, Run-Zhu.,...&Ye, Wen-Cai.(2017).Meloslines A and B, two novel indole alkaloids from Alstonia scholaris.TETRAHEDRON LETTERS,58(28),2740-2742.
MLA Kuok, Chiu-Fai,et al."Meloslines A and B, two novel indole alkaloids from Alstonia scholaris".TETRAHEDRON LETTERS 58.28(2017):2740-2742.
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