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Characterization of potential driver mutations involved in human breast cancer by computational approaches
Rajendran, Barani Kumar; Deng, Chu-Xia
2017-07-25
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:30Pages:50252-50272
Abstract

Breast cancer is the second most frequently occurring form of cancer and is also the second most lethal cancer in women worldwide. A genetic mutation is one of the key factors that alter multiple cellular regulatory pathways and drive breast cancer initiation and progression yet nature of these cancer drivers remains elusive. In this article, we have reviewed various computational perspectives and algorithms for exploring breast cancer driver mutation genes. Using both frequency based and mutational exclusivity based approaches, we identified 195 driver genes and shortlisted 63 of them as candidate drivers for breast cancer using various computational approaches. Finally, we conducted network and pathway analysis to explore their functions in breast tumorigenesis including tumor initiation, progression, and metastasis.

KeywordDriver Mutations Breast Cancer Cancer Drivers Breast Cancer Driver Genes Genetic Mutations
DOI10.18632/oncotarget.17225
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000406232400146
PublisherIMPACT JOURNALS LLC
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:20   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDeng, Chu-Xia
AffiliationCancer Research Centre, Faculty of Health Sciences, University of Macau, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Rajendran, Barani Kumar,Deng, Chu-Xia. Characterization of potential driver mutations involved in human breast cancer by computational approaches[J]. ONCOTARGET,2017,8(30):50252-50272.
APA Rajendran, Barani Kumar,&Deng, Chu-Xia.(2017).Characterization of potential driver mutations involved in human breast cancer by computational approaches.ONCOTARGET,8(30),50252-50272.
MLA Rajendran, Barani Kumar,et al."Characterization of potential driver mutations involved in human breast cancer by computational approaches".ONCOTARGET 8.30(2017):50252-50272.
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