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In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement
Yue Zhao1; Shaozhuang Yang1; Yating Wang2; Zhen Yuan2; Junle Qu1; Liwei Liu1
2018-10
Source PublicationAPPLIED PHYSICS LETTERS
ISSN0003-6951
Volume113Issue:14
Abstract

In this letter, we proposed a photoacoustic (PA) method for noninvasively detecting blood viscosity in subcutaneous microvasculature with the frequency-resolved measurement. The influence of viscosity on PA generation was investigated theoretically, and a negative correlation was shown between the viscosity and the full width at half maximum (FWHM) of the PA frequency spectrum, which can be utilized to reflect the viscosity distribution. To test the feasibility and accuracy of this method, water mixed with different concentrations of glycerol was measured. FWHM of the PA frequency spectrum was also obtained in vivo in the mouse ear to characterize the blood viscosity from different vessel bifurcations, and the metabolism-induced viscosity changes were dynamically monitored in the microvasculature. Experimental results demonstrate that this technique has future potential clinical applications for real-time monitoring the viscosity changes in subcutaneous microvasculature. Published by AIP Publishing.

DOI10.1063/1.5039538
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPhysics
WOS SubjectPhysics, Applied
WOS IDWOS:000446820600035
PublisherAMER INST PHYSICS
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorLiwei Liu
Affiliation1.Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China
2.Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, China
Recommended Citation
GB/T 7714
Yue Zhao,Shaozhuang Yang,Yating Wang,et al. In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement[J]. APPLIED PHYSICS LETTERS,2018,113(14).
APA Yue Zhao,Shaozhuang Yang,Yating Wang,Zhen Yuan,Junle Qu,&Liwei Liu.(2018).In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement.APPLIED PHYSICS LETTERS,113(14).
MLA Yue Zhao,et al."In vivo blood viscosity characterization based on frequency-resolved photoacoustic measurement".APPLIED PHYSICS LETTERS 113.14(2018).
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