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Micro-NMR on CMOS for biomolecular sensing
Ka-Meng Lei1; Nan Sun2; Pui-In Mak1; Rui Paulo Martins1,3; Donhee Ham4
Source PublicationCMOS Circuits for Biological Sensing and Processing Systems
Author of SourceMitra, Srinjoy, Cumming, David R. S.
PublisherSpringer International Publishing

In this chapter, we reported several portable nuclear magnetic resonance (NMR) systems implemented with silicon integrated circuits (IC). Being the initial researchers in the NMR on IC field, we firstly proposed to integrate the complex NMR electronics with the customized IC for portable NMR application with a palm size magnet. Moreover, to manage the samples inside the narrow opening of the portable magnet, we proposed the integration of the digital microfluidic device with the portable NMR system to attain electronic-automated multi-sample management scheme. With the capacitive sensing module of the droplets, the samples can be guided to the NMR sensing site sequentially to reduce labor and experimental time, which facilitates the detection and supports high-throughput sensing. Lastly, we demonstrates a NMR system with magnetic field calibration. This calibration culminates in a robust NMR sensing scheme by modulating the actual magnetic field to a steady value. Thus, the Larmor frequency can be stabilized, and the NMR sensing can work at different environment.

KeywordNuclear Magnetic Resonance (Nmr) Radio-frequency (Rf) Integrated Circuits Cmos Biomolecular Sensing Sample Management B-field Calibration
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Document TypeBook chapter
CollectionFaculty of Science and Technology
Affiliation1.State Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECE, University of Macau, Macau, China
2.School of Engineering and Applied SciencesHarvard UniversityCambridgeUSA
3.Department of Electrical and Computer EngineeringUniversity of Texas at AustinAustinUSA
4.Instituto Superior TécnicoUniversidade de LisboaLisboaPortugal
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Ka-Meng Lei,Nan Sun,Pui-In Mak,et al. Micro-NMR on CMOS for biomolecular sensing:Springer International Publishing,2018:101-132.
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