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MiRNA-target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis
Liu, Yamin1; Wang, Mei2; Luo, Yunquan3; Chen, ChenJian1; Lu, Yiyu1; Shi, Yulin1; Tang, Chenchen1; Zhou, Qianmei1; Zhang, Hui1; Hu, Yuanjia4; Su, Shibing1; Chen, Qilong1
2017-09-08
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7
Abstract

Hepatitis B is one of most etiologies of Liver cirrhosis in China, and clinically lacks the effective strategy for Hepatitis B caused cirrhosis (HBC) therapy. As a complementary and alternative medicine, Chinese Traditional Medicine (TCM) has special therapeutic effects for HBC. Here, we focus on the evolution process of HBC TCM syndromes, which was from Excessive (Liver-Gallbladder Dampness-Heat Syndrome, LGDHS) to Deficient (Liver-Kidney Deficiency Syndrome, LKYDS) via Excessive-Deficient syndrome (Liver-Depression and Spleen-Deficiency Syndrome, LDSDS). Using R package, 16 miRNAs in LGDHS/Normal, 48 miRNAs in LDSDS/LGDHS, and 16 miRNAs in LKYDS/LDSDS were identified, respectively. The miRNA-target networks show that the LDSDS was most stability and complicated. Subsequently, 4 kernel miRNAs with LGDHS-LDSDS process, and 5 kernel miRNAs with LDSDS-LKYDS process were screened. Using RT-qPCR data, p1 (hsa-miR-17-3p, -377-3p, -410-3p and -495) and p2 miRNA panel (hsa-miR-377-3p, -410-3p, -27a-3p, 149-5p and 940) were identified by Logistic Regression Model, which clearly improve the accuracy of TCM syndrome classification. The rebuilt miRNA-target network shows that the LDSDS is a critical point and might determine the evolution directions of HBC TCM syndrome. This study suggests that the identified kernel miRNAs act as potential biomarkers and benefit to evaluate the evolution tendency of HBC TCM syndromes.

DOI10.1038/s41598-017-11351-5
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000409841100116
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSu, Shibing; Chen, Qilong
Affiliation1.Research Center for TCM Complexity System, Shanghai University of TCM, Shanghai, 201203, China
2.School of Clinical Medicine, Shanghai University of Medicine & Health Sciences, Shanghai, 201203, China
3.Shu Guang Hospital Afliated to Shanghai University of TCM, Shanghai, 201203, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Liu, Yamin,Wang, Mei,Luo, Yunquan,et al. MiRNA-target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Yamin,Wang, Mei,Luo, Yunquan,Chen, ChenJian,Lu, Yiyu,Shi, Yulin,Tang, Chenchen,Zhou, Qianmei,Zhang, Hui,Hu, Yuanjia,Su, Shibing,&Chen, Qilong.(2017).MiRNA-target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis.SCIENTIFIC REPORTS,7.
MLA Liu, Yamin,et al."MiRNA-target network analysis identifies potential biomarkers for Traditional Chinese Medicine (TCM) syndrome development evaluation in hepatitis B caused liver cirrhosis".SCIENTIFIC REPORTS 7(2017).
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