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1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy
Yang, Yu1; Zhu, Wenjun2; Dong, Ziliang2; Chao, Yu2; Xu, Lai2; Chen, Meiwan1; Liu, Zhuang2
2017-10-25
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume29Issue:40
Abstract

Near-infrared (NIR)-light-triggered photothermal therapy (PTT) usually requires hyperthermia to > 50 degrees C for effective tumor ablation, which can potentially induce inflammatory disease and heating damage of normal organs nearby, while tumor lesions without sufficient heating (e.g., the internal part) may survive after treatment. Achieving effective tumor killing under relatively low temperatures is thus critical toward successful clinical use of PTT. Herein, we design a simple strategy to fabricate poly(ethylene glycol) (PEG)modified one-dimensional nanoscale coordination polymers (1D-NCPs) with intrinsic biodegradability, large surface area, pH-responsive behaviors, and versatile theranostic functions. With NCPs consisting of Mn2+/ indocyanine green (ICG) as the example, Mn-ICG@pHis-PEG display efficient pH-responsive tumor retention after systemic administration and then load Gambogic acid (GA), a natural inhibitor of heat-shock protein 90 (Hsp90) that plays an essential role for cells to resist heating-induced damage. Such Mn-ICG@pHis-PEG/GA under a mild NIR-triggered heating is able to induce effective apoptosis of tumor cells, realizing low-temperature PTT (similar to 43 degrees C) with excellent tumor destruction efficacy. This work not only develops a facile approach to fabricate PEGylated 1D-NCPs with tumor-specific pH responsiveness and theranostic functionalities, but also presents a unique low-temperature PTT strategy to kill cancer in a highly effective and minimally invasive manner.

KeywordCancer Theranostics Coordination-polymer Nanofibers Drug Delivery Gambogic Acid Low-temperature Photothermal Therapy
DOI10.1002/adma.201703588
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000413406200021
PublisherWILEY-V C H VERLAG GMBH
The Source to ArticleWOS
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Cited Times [WOS]:152   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical Sciences, University of Macau, 999078 Macau, China
2.Institute of Functional Nano & Soft Materials Laboratory (FUNSOM)Soochow University, Suzhou, Jiangsu 215123, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yang, Yu,Zhu, Wenjun,Dong, Ziliang,et al. 1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy[J]. ADVANCED MATERIALS,2017,29(40).
APA Yang, Yu,Zhu, Wenjun,Dong, Ziliang,Chao, Yu,Xu, Lai,Chen, Meiwan,&Liu, Zhuang.(2017).1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy.ADVANCED MATERIALS,29(40).
MLA Yang, Yu,et al."1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy".ADVANCED MATERIALS 29.40(2017).
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