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Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta-analysis
Yuan, Rong1,2; Xin, Qiqi2; Shi, Weili2; Liu, Wei3; Lee, Simon-M.4; Hoi, Puiman4; Li, Lin5; Zhao, Jun6; Cong, Weihong2; Chen, Keji2
2018-10
Source PublicationCARDIOVASCULAR THERAPEUTICS
ISSN1755-5914
Volume36Issue:5
Other Abstract

Aim: It is not clear whether treatment by vascular endothelial growth factor (VEGF) gene transfer can improve myocardial ischemia through a proangiogenesis mechanism and is effective against coronary artery disease (CAD). We aimed to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) that compared VEGF gene therapy and standard treatments in CAD.

Methods: We systematically searched the PubMed, Embase, and Cochrane databases and relevant references for RCTs (published up to May 2018; no language restrictions) and performed meta-analysis using both fixed and random effects models. Our primary outcome measures were mortality and serious cardiac events. The secondary outcome measures were follow-up left ventricular ejection fraction (LVEF), change in LVEF (LVEF), and angina outcomes. The registration number is CRD42017058430.

Results: Of 524 identified studies, 14 were eligible and were included in our analysis. At a mean follow-up of 6months, VEGF gene therapy demonstrated a decreased risk of serious cardiac events (11.7% vs 21.2%, relative risk: 0.56; 95% confidence interval (CI): 0.37, 0.84; P=0.005) and a slight improvement in follow-up LVEF (weighted mean difference: 1.95; 95%CI: 1.28, 2.62). Furthermore, VEGF gene therapy using adenoviral vectors showed more potential benefit in terms of the risk of serious cardiac events, LVEF, and Canadian Cardiovascular Society angina class. Nevertheless, mortality and angina frequency scores were not different.

Conclusions: Vascular endothelial growth factor gene therapy appears to be safe and effective regarding serious cardiac events, with greater benefit when using adenoviral vectors. This meta-analysis highlights the need for further exploration in these areas.

KeywordAngina Pectoris Angiogenesis Inducing Agents Coronary Artery Disease Genetic Therapy Myocardial Ischemia Vascular Endothelial Growth Factor
DOI10.1111/1755-5922.12461
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaCardiovascular System & Cardiology ; Pharmacology & Pharmacy
WOS SubjectCardiac & Cardiovascular Systems ; Pharmacology & Pharmacy
WOS IDWOS:000444410000010
PublisherWILEY
The Source to ArticleWOS
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorCong, Weihong; Chen, Keji
Affiliation1.Graduate School, Beijing University of Chinese Medicine, Beijing, China
2.Laboratory of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China
3.Cardiovascular Department, Beijing Hospital of TCM Affiliated to the Capital Medical University, Beijing, China
4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
5.Laboratory of Neurodegenerative Diseases, Xuanwu Hospital, Capital Medical University, Beijing, China
6.Traditional Chinese Medicine Department, The Affiliated Hospital of Qingdao University, Qingdao, China
Recommended Citation
GB/T 7714
Yuan, Rong,Xin, Qiqi,Shi, Weili,et al. Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta-analysis[J]. CARDIOVASCULAR THERAPEUTICS,2018,36(5).
APA Yuan, Rong,Xin, Qiqi,Shi, Weili,Liu, Wei,Lee, Simon-M.,Hoi, Puiman,Li, Lin,Zhao, Jun,Cong, Weihong,&Chen, Keji.(2018).Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta-analysis.CARDIOVASCULAR THERAPEUTICS,36(5).
MLA Yuan, Rong,et al."Vascular endothelial growth factor gene transfer therapy for coronary artery disease: A systematic review and meta-analysis".CARDIOVASCULAR THERAPEUTICS 36.5(2018).
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