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Synthesis of Magnetic, Up‐Conversion Luminescent, and Mesoporous Core–Shell‐Structured Nanocomposites as Drug Carriers
Shili Gai2; Piaoping Yang1; Chunxia Li1; Wenxin Wang2; Yunlu Dai1; Na Niu2; Jun Lin1
2010
Source PublicationAdvanced Functional Materials
ISSN1616-301X
Volume20Pages:1166–1172
Abstract

The synthesis (by a facile two‐step sol–gel process), characterization, and application in controlled drug release is reported for monodisperse core–shell‐structured Fe3O4@nSiO2@mSiO2@NaYF4: Yb3+, Er3+/Tm3+ nanocomposites with mesoporous, up‐conversion luminescent, and magnetic properties. The nanocomposites show typical ordered mesoporous characteristics and a monodisperse spherical morphology with narrow size distribution (around 80 nm). In addition, they exhibit high magnetization (38.0 emu g−1, thus it is possible for drug targeting under a foreign magnetic field) and unique up‐conversion emission (green for Yb3+/Er3+ and blue for Yb3+/Tm3+) under 980 nm laser excitation even after loading with drug molecules. Drug release tests suggest that the multifunctional nanocomposites have a controlled drug release property. Interestingly, the up‐conversion emission intensity of the multifunctional carrier increases with the released amount of model drug, thus allowing the release process to be monitored and tracked by the change of photoluminescence intensity. This composite can act as a multifunctional drug carrier system, which can realize the targeting and monitoring of drugs simultaneously.

DOIhttps://doi.org/10.1002/adfm.200902274
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS IDWOS:000276775600015
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Cited Times [WOS]:486   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPiaoping Yang; Jun Lin
Affiliation1.State Key Laboratory of Rare Earth Resource UtilizationChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 (P. R. China)
2.College of Material Science and Chemical EngineeringHarbin Engineering University Harbin 150001 (P. R. China)
Recommended Citation
GB/T 7714
Shili Gai,Piaoping Yang,Chunxia Li,et al. Synthesis of Magnetic, Up‐Conversion Luminescent, and Mesoporous Core–Shell‐Structured Nanocomposites as Drug Carriers[J]. Advanced Functional Materials,2010,20:1166–1172.
APA Shili Gai,Piaoping Yang,Chunxia Li,Wenxin Wang,Yunlu Dai,Na Niu,&Jun Lin.(2010).Synthesis of Magnetic, Up‐Conversion Luminescent, and Mesoporous Core–Shell‐Structured Nanocomposites as Drug Carriers.Advanced Functional Materials,20,1166–1172.
MLA Shili Gai,et al."Synthesis of Magnetic, Up‐Conversion Luminescent, and Mesoporous Core–Shell‐Structured Nanocomposites as Drug Carriers".Advanced Functional Materials 20(2010):1166–1172.
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