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Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells
Lam, IPY1; Lee, LTO1; Choi, HS2; Chow, BKC1
2006
Conference Name7th International Symposium on VIP, PACAP and Related Peptides
Source PublicationVIP, PACAP, AND RELATED PEPTIDES: FROM GENE TO THERAPY
Volume1070
Pages371-375
Conference DateSEP 11-14, 2005
Conference PlaceRouen, FRANCE
Author of SourceVaudry, H; Laburthe, M
Abstract

Previous studies have demonstrated the transcriptional repressive property of the atypical nuclear receptor, small heterodimer partner (SHP), on NeuroD. NeuroD is a basic helix-loop-helix transcription factor that has also been shown to be important in modulating secretin gene expression. The present study revealed the activation of the human secretin core promotor by overexpressing NeuroD, and the localization of SHP and secretin-producing cells in mouse duodenal epithelium by immunohistochemical stainings. These results indicated that SHP and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroWs positive regulatory activity on secretin gene.

KeywordSecretin Neurod Small Heterodimer Partner
DOIhttps://doi.org/10.1196/annals.1317.047
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Science & Technology - Other Topics ; Neurosciences & Neurology
WOS SubjectBiochemistry & Molecular Biology ; Multidisciplinary Sciences ; Neurosciences
WOS IDWOS:000240364200051
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionFaculty of Health Sciences
Affiliation1.Department of Zoology, The University of Hong Kong, Hong Kong, China
2.Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Republic of Korea
Recommended Citation
GB/T 7714
Lam, IPY,Lee, LTO,Choi, HS,et al. Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells[C]//Vaudry, H; Laburthe, M,2006:371-375.
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