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A smart tumor microenvironment responsive nanoplatform based on upconversion nanoparticles for efficient multimodal imaging guided therapy
Shikai Liu1; Wenting Li1; Shili Gai1; Guixin Yang1; Chongna Zhong1; Yunlu Dai1; Fei He1; Piaoping Yang1; Yung Doug Suh2,3
2019
Source PublicationBiomaterials Science
ISSN2047-4830
Abstract

Near-infrared (NIR) light-induced imaging-guided cancer therapy has been studied extensively in recent years. Herein, we report a novel theranostic nanoplatform by modifying polyoxometalate (POM) nanoclusters onto mesoporous silica-coated upconversion nanoparticles (UCNPs), followed by loading doxorubicin (DOX) in the mesopores and coating a folate–chitosan shell onto the surface. In this nanoplatform, the core–shell structured UCNPs (NaYF4:Yb,Er@NaYF4:Yb,Nd) showed special upconverting luminescence (UCL) when irradiated with high-penetration 808 nm NIR light, and the doped Yb and Nd ions endowed the sample with CT imaging properties, thus achieving a dual-mode imaging function. Moreover, the simultaneously generated heat mediated by the 808 nm NIR light may coordinate with the chemotherapy generated from the released DOX to realize an efficient synergistic therapy, verified by diverse in vitro and in vivo assays. The coated folate–chitosan shell can target the platform to tumor tissues when it was transported in the blood vessels and accumulated in tumor sites via the enhanced permeability and retention effect (EPR). Due to the acidic and reductive microenvironment of the tumor, the DOX released quickly with the dissolved folate–chitosan shell, exhibiting obvious tumor microenvironment (TME) responsive properties. The smart imaging-guided therapeutic nanoplatform should be highly promising in TME responsive therapy.

DOI10.1039/C8BM01243A
Language英语
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorShili Gai; Fei He; Piaoping Yang; Yung Doug Suh
Affiliation1.Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China
2.Research Center for Bio Platform Technology, Korea Research Institute of Chemical Technology (KRICT), Yuseong P.O. Box 107, DaeJeon 305-600, Korea.
3.School of Chemical Engineering, SungKyunKwan University (SKKU)
Recommended Citation
GB/T 7714
Shikai Liu,Wenting Li,Shili Gai,et al. A smart tumor microenvironment responsive nanoplatform based on upconversion nanoparticles for efficient multimodal imaging guided therapy[J]. Biomaterials Science,2019.
APA Shikai Liu,Wenting Li,Shili Gai,Guixin Yang,Chongna Zhong,Yunlu Dai,Fei He,Piaoping Yang,&Yung Doug Suh.(2019).A smart tumor microenvironment responsive nanoplatform based on upconversion nanoparticles for efficient multimodal imaging guided therapy.Biomaterials Science.
MLA Shikai Liu,et al."A smart tumor microenvironment responsive nanoplatform based on upconversion nanoparticles for efficient multimodal imaging guided therapy".Biomaterials Science (2019).
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