UM  > Faculty of Health Sciences
Multifunctional SiO2@Gd2O3:Yb/Tm Hollow Capsules: Controllable Synthesis and Drug Release Properties
Guixin Yang; Ruichan Lv; Shili Gai; Yunlu Dai; Fei He; Piaoping Yang
2014-10-20
Source PublicationInorganic chemistry
ISSN0020-1669
Volume53Issue:20Pages:10917-10927
Abstract

A series of hollow and luminescent capsules have been fabricated by covering luminescent Gd2O3:Yb/Tm nanoparticles on the surface of uniform hollow mesoporous silica capsules (HMSCs), which were obtained from an etching process using Fe3O4 as hard templates. X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), up-conversion (UC) fluorescence spectra, and N2 adsorption−desorption were used to characterize these samples. It is found that the as-prepared products have mesoporous pores, large specific surface, and high dispersity. In particular, the size, shape, surface area, and interior space of the composites can be finely tuned by adjusting the size and morphology of the magnetic cores. Under 980 nm nearinfrared (NIR) laser irradiation, the composites show characteristic blue UC emissions of Tm3+ even after carrying doxorubicin hydrochloride (DOX). The drug-release test reveals that the capsules showed an apparent sustained release character and released in a pH-sensitive manner. Interestingly, the UC luminescence intensity of the drug-carrying system increases with the released DOX, realizing the possibility to track or monitor the released drug by the change of UC fluorescence simultaneously, which should be highly promising in anticancer drug delivery and targeted cancer therapy

DOI10.1021/ic501121t
Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000343527700020
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Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorPiaoping Yang
AffiliationKey Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China
Recommended Citation
GB/T 7714
Guixin Yang,Ruichan Lv,Shili Gai,et al. Multifunctional SiO2@Gd2O3:Yb/Tm Hollow Capsules: Controllable Synthesis and Drug Release Properties[J]. Inorganic chemistry,2014,53(20):10917-10927.
APA Guixin Yang,Ruichan Lv,Shili Gai,Yunlu Dai,Fei He,&Piaoping Yang.(2014).Multifunctional SiO2@Gd2O3:Yb/Tm Hollow Capsules: Controllable Synthesis and Drug Release Properties.Inorganic chemistry,53(20),10917-10927.
MLA Guixin Yang,et al."Multifunctional SiO2@Gd2O3:Yb/Tm Hollow Capsules: Controllable Synthesis and Drug Release Properties".Inorganic chemistry 53.20(2014):10917-10927.
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