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A cheap and facile route to synthesize monodisperse magnetic nanocrystals and their application as MRI agents
Guixin Yang1; Fei He1; Ruichan Lv1; Shili Gai1; Ziyong Cheng2; Yunlu Dai1; Piaoping Yang1
2015
Source PublicationDalton transactions
ISSN1477-9226
Volume44Pages:247-253
Abstract

A facile solution-based thermal decomposition strategy, using very cheap polyisobutylene succimide (PIBSI) and paraffin oil as a surfactant and solvent, respectively, has been developed for the controllable synthesis of magnetic MnFe2O4 and CoFe2O4 nanocrystals (NCs) with high dispersibility, uniform shape, and high yield. By fine-tuning the reaction temperature and growth time, the morphology and size of MnFe2O4 and CoFe2O4 NCs can be simply regulated. It is found that the surfactant PIBSI plays a key role in the final shape of the products due to its long chain with non-polar groups, which can markedly hinder the aggregation of the NCs and thus greatly improve the stability and dispersibility of the products. The results reveal that MnFe2O4 and CoFe2O4 NCs have good biocompatibility and obvious T2 contrast enhancement effects have been achieved with the increase of iron concentration. MnFe2O4 and CoFe2O4 NCs show high longitudinal relaxivity of 165.6 and 65.143 mM−1 S−1 in aqueous solutions due to the positive signal enhancement ability of Fe3+ ions, indicating the highly potential to be used as effective T2 contrast agents for magnetic resonance imaging (MRI).

DOI10.1039/C4DT02425G
Indexed BySCIE
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Inorganic & Nuclear
WOS IDWOS:000346408900033
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorFei He; Piaoping Yang
Affiliation1.Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China.
2.State Key Laboratory of Rare Source Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130021, P. R. China
Recommended Citation
GB/T 7714
Guixin Yang,Fei He,Ruichan Lv,et al. A cheap and facile route to synthesize monodisperse magnetic nanocrystals and their application as MRI agents[J]. Dalton transactions,2015,44:247-253.
APA Guixin Yang,Fei He,Ruichan Lv,Shili Gai,Ziyong Cheng,Yunlu Dai,&Piaoping Yang.(2015).A cheap and facile route to synthesize monodisperse magnetic nanocrystals and their application as MRI agents.Dalton transactions,44,247-253.
MLA Guixin Yang,et al."A cheap and facile route to synthesize monodisperse magnetic nanocrystals and their application as MRI agents".Dalton transactions 44(2015):247-253.
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